Effect of Cosopt Versus Combigan on Retinal Vascular Autoregulation in Primary Open Angle Glaucoma (POAG)
Information source: Massachusetts Eye and Ear Infirmary
Information obtained from ClinicalTrials.gov on February 07, 2013
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Glaucoma
Intervention: Cosopt (Drug); Combigan (Drug)
Phase: N/A
Status: Recruiting
Sponsored by: Massachusetts Eye and Ear Infirmary
Summary
We have completed a study in which we examined the response of the retinal circulation to
changes in posture from sitting to lying down in patients with primary open angle glaucoma
(POAG). This alteration in position produces changes in the local blood pressure at the
entrance to the retinal vasculature. In a healthy retina, the vasculature adapts by
dilating and constricting in order to maintain a steady blood flow rate. In an eye with
POAG, this often does not occur. As a result, there are large fluctuations in blood flow
which may produce the retinal neuronal damage associated with glaucoma.
The purpose of this study is to demonstrate that topical anti-glaucoma treatments with
agents that have vasoactive as well as IOP-lowering effects can have a beneficial effect on
maintaining a steady retinal blood flow rate even when there are changes in local blood
pressure.
Clinical Details
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Investigator), Primary Purpose: Basic Science
Primary outcome: Change in retinal blood flow with increase in perfusion pressure due to posture change
Eligibility
Minimum age: 40 Years.
Maximum age: 80 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- POAG
- Age 40 to 80 years
- Untreated IOP greater than 21 mm Hg
Exclusion Criteria:
- More than two IOP lowering medications
- Exfoliation or pigment dispersion syndrome
- Diabetic retinopathy
- History of ocular surgery
Locations and Contacts
Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, United States; Recruiting
Louis R Pasquale, MD, Phone: 617-573-4270, Email: Louis_Pasquale@meei.harvard.edu
Louis R Pasquale, MD, Principal Investigator
Additional Information
Related publications: Feke GT, Pasquale LR. Retinal blood flow response to posture change in glaucoma patients compared with healthy subjects. Ophthalmology. 2008 Feb;115(2):246-52. Epub 2007 Aug 8.
Starting date: January 2009
Last updated: April 19, 2012
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