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Local Anaesthetic for Transvaginal Egg Collection in IVF

Information source: The Fertility Centre, New Zealand
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Infertility

Intervention: lignocaine (Drug); normal saline (Drug)

Phase: N/A

Status: Completed

Sponsored by: The Fertility Centre, New Zealand

Official(s) and/or principal investigator(s):
Sarah A Wakeman, FRANZCOG, Principal Investigator, Affiliation: The Fertility Centre

Summary

The purpose of this study is to see whether injecting local anaesthetic into the vaginal tissues,just prior to transvaginal egg collection,will decrease the amount of pain experienced by women having their eggs collected on an IVF cycle. All women will also receive intravenous sedation as required as well as a sleeping tablet thirty minutes prior to the procedure which is our routine procedure for egg collection.

Clinical Details

Official title: A Randomised Controlled Trial of Intravaginal Lignocaine Injection Versus Placebo for Analgesia During Oocyte Recovery in an IVF Cycle

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Supportive Care

Primary outcome: Total dose of iv fentanyl used during oocyte collection

Secondary outcome:

Pain score (cm on a Visual Analogue Scale) at 6 different points during oocyte collection

Length of oocyte collection procedure

Occurence of nausea or vomiting

Administration of atropine or anti -emetic

Time spent in recovery room

No of oocytes collected

Number of oocytes fertilised

Pregnancy outcome

Number of embryos frozen

Pulse rate at beginning and end of egg collection

Maximum pulse rate during oocyte collection

Detailed description: Transvaginal oocyte retrieval is the most common method of oocyte collection in IVF cycles. A variety of different methods are used to provide analgesia/anesthesia for oocyte collection. Our unit has always used an oral pre-medication followed by intravenous fentanyl during the procedure but this doesn't seem to provide adequate analgesia for some women. The aim of this study was to compare the addition of intravaginal local anaesthetic injection versus saline placebo to our usual analgesia regime to see whether less intravenous fentanyl was required and whether the women experienced less pain during oocyte collection.

Eligibility

Minimum age: N/A. Maximum age: N/A. Gender(s): Female.

Criteria:

Inclusion Criteria:

- About to undergo transvaginal oocyte retrieval

Exclusion Criteria:

- Already undergone oocyte retrieval and participated in study (i. e. 2nd or more oocyte

collection procedure during study period)

- Allergy to lignocaine

- Oocytes only to be collected from one ovary

- Procedure expected to be exceptionally painful

Locations and Contacts

The Fertility Centre, Christchurch, Canterbury 8014, New Zealand
Additional Information

Starting date: March 2002
Last updated: November 5, 2007

Page last updated: August 20, 2015

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