Local Anaesthetic for Transvaginal Egg Collection in IVF
Information source: The Fertility Centre, New Zealand
ClinicalTrials.gov processed this data on August 20, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Infertility
Intervention: lignocaine (Drug); normal saline (Drug)
Phase: N/A
Status: Completed
Sponsored by: The Fertility Centre, New Zealand Official(s) and/or principal investigator(s): Sarah A Wakeman, FRANZCOG, Principal Investigator, Affiliation: The Fertility Centre
Summary
The purpose of this study is to see whether injecting local anaesthetic into the vaginal
tissues,just prior to transvaginal egg collection,will decrease the amount of pain
experienced by women having their eggs collected on an IVF cycle. All women will also
receive intravenous sedation as required as well as a sleeping tablet thirty minutes prior
to the procedure which is our routine procedure for egg collection.
Clinical Details
Official title: A Randomised Controlled Trial of Intravaginal Lignocaine Injection Versus Placebo for Analgesia During Oocyte Recovery in an IVF Cycle
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Supportive Care
Primary outcome: Total dose of iv fentanyl used during oocyte collection
Secondary outcome: Pain score (cm on a Visual Analogue Scale) at 6 different points during oocyte collectionLength of oocyte collection procedure Occurence of nausea or vomiting Administration of atropine or anti -emetic Time spent in recovery room No of oocytes collected Number of oocytes fertilised Pregnancy outcome Number of embryos frozen Pulse rate at beginning and end of egg collection Maximum pulse rate during oocyte collection
Detailed description:
Transvaginal oocyte retrieval is the most common method of oocyte collection in IVF cycles.
A variety of different methods are used to provide analgesia/anesthesia for oocyte
collection. Our unit has always used an oral pre-medication followed by intravenous fentanyl
during the procedure but this doesn't seem to provide adequate analgesia for some women. The
aim of this study was to compare the addition of intravaginal local anaesthetic injection
versus saline placebo to our usual analgesia regime to see whether less intravenous fentanyl
was required and whether the women experienced less pain during oocyte collection.
Eligibility
Minimum age: N/A.
Maximum age: N/A.
Gender(s): Female.
Criteria:
Inclusion Criteria:
- About to undergo transvaginal oocyte retrieval
Exclusion Criteria:
- Already undergone oocyte retrieval and participated in study (i. e. 2nd or more oocyte
collection procedure during study period)
- Allergy to lignocaine
- Oocytes only to be collected from one ovary
- Procedure expected to be exceptionally painful
Locations and Contacts
The Fertility Centre, Christchurch, Canterbury 8014, New Zealand
Additional Information
Starting date: March 2002
Last updated: November 5, 2007
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