Stem Cell Transplantation for the Treatment of Knee Osteoarthritis
Information source: Tehran University of Medical Sciences
Information obtained from ClinicalTrials.gov on February 12, 2009
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Knee Osteoarthritis
Intervention: Autologous Stem Cell Transplantation (Biological)
Phase: Phase 1
Status: Recruiting
Sponsored by: Tehran University of Medical Sciences Official(s) and/or principal investigator(s):
Fereydoun Davatchi, MD, Study Chair, Affiliation: Rheumatology Research Center, Medical Sciences/University of Teheran
Behrouz Nikbin, MD, Principal Investigator, Affiliation: Department of Immunology, Medical Sciences/University of Tehran
Overall contact:
Fereydoun Davatchi, MD, Phone: (98-21) 8802-6956, Email: fddh@davatchi.net
Summary
The purpose of this study is to find if autologous stem cell transplantation can improve
clinical manifestations of knee osteoarthritis.
Clinical Details
Official title: Phase 1 Study of Bone Marrow - Derived Stem Cell for the Treatment of Knee Osteoarthritis
Study design: Treatment, Non-Randomized, Open Label, Single Group Assignment, Safety/Efficacy Study
Primary outcome: 1- Comparison of pain in the injected knee with the controlateral knee
2- Comparison of joint motion of the injected knee with the controlateral knee
Secondary outcome: Evaluation of side-effects
Eligibility
Minimum age: 40 Years.
Maximum age: 70 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Moderate bilateral knee osteoarthritis
Exclusion Criteria:
- No infectious or inflammatory arthritis
Locations and Contacts
Fereydoun Davatchi, MD, Phone: (98-21) 8802-6956, Email: fddh@davatchi.net
Rheumatology Research Center, Behcet's Disease Unit (Shariati Hospital), Tehran 14114, Iran, Islamic Republic of; Recruiting
Fereydoun Davatchi, MD, Phone: (98-21)8802-6956, Email: fddh@davatchi.net
Fereydoun Davatchi, MD, Principal Investigator
Bahar Sadeghi-Abdollahi, MD, Sub-Investigator
Masoomeh Akhlaghi, MD, Sub-Investigator
Tahereh Faezi, MD, Sub-Investigator
Additional Information
Related publications: Le Blanc K. [Mesenchymal stem cells. Basic science and future clinical use] Lakartidningen. 2002 Mar 21;99(12):1318-21, 1324. Review. Swedish. Caplan AI. Mesenchymal stem cells. J Orthop Res. 1991 Sep;9(5):641-50. Caplan AI, Elyaderani M, Mochizuki Y, Wakitani S, Goldberg VM. Principles of cartilage repair and regeneration. Clin Orthop Relat Res. 1997 Sep;(342):254-69. Solchaga LA, Welter JF, Lennon DP, Caplan AI. Generation of pluripotent stem cells and their differentiation to the chondrocytic phenotype. Methods Mol Med. 2004;100:53-68. Caplan AI. Adult mesenchymal stem cells for tissue engineering versus regenerative medicine. J Cell Physiol. 2007 Nov;213(2):341-7.
Starting date: December 2007
Ending date: June 2010
Last updated: February 7, 2009
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