Mechanisms of Human Cutaneous Microcirculation in Healthy Volunteers
Information source: University Hospital, Angers
Information obtained from ClinicalTrials.gov on February 07, 2013
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Healthy Volunteers
Intervention: pressure strain system, iontophoresis (Device); scopolamin (Drug); emla (Drug); capsaicin (Drug); aspirin (Drug); clopidogrel (Drug); celecoxib (Drug); indomethacin (Drug); acetylcholine (Drug); sodium nitroprusside (Drug); brethyllium (Drug); general and local heating (Device)
Phase: Phase 4
Status: Recruiting
Sponsored by: University Hospital, Angers Official(s) and/or principal investigator(s):
Jean Louis SAUMET, MD - PhD, Principal Investigator, Affiliation: University Hospital, Angers
Overall contact:
Pierre ABRAHAM, MD, PhD, Phone: (0)2-41-35-46-17, Ext: 33, Email: piabraham@chu-angers.fr
Summary
Microvascular dysfunctions are critical events in several diseases including diabetes. This
study will develop a methodology for microvascular investigation in human skin. The purpose
of the study is to investigate the physiological response of the cutaneous microcirculation
to physical, thermal, mechanical or chemical stimulations.
Clinical Details
Official title: Etude de la Reserve Vasomotrice Microcirculatoire cutanée
Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Diagnostic
Primary outcome: Amplitude of the vasomotor response to stimuli
Secondary outcome: Kinetics of the vasomotor response to stimuli
Detailed description:
This study has investigated various aspects of the physiology of the microcirculation in the
past years and is still recruiting under parallel protocols of physiological investigations
of the neurovascular control of the cutaneous microcirculation.
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Healthy volunteers with no clinical signs of, or risk factors for, vascular disease
Exclusion Criteria:
- Smokers, Pregnancy, Allergy,
Locations and Contacts
Pierre ABRAHAM, MD, PhD, Phone: (0)2-41-35-46-17, Ext: 33, Email: piabraham@chu-angers.fr
Laboratoire de Physiologie et Explorations Vasculaires - CHU Angers, Angers 49033, France; Recruiting
Pierre ABRAHAM, MD, PhD, Phone: (0)2-41-35-46-17, Ext: 33, Email: piabraham@chu-angers.fr
Additional Information
Starting date: January 1996
Last updated: March 16, 2007
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