Effects of Epinephrine and Intravenous (I.V.) Needle on Cardiopulmonary Resuscitation (CPR) Outcome
Information source: University of Oslo
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Cardiac Arrest
Intervention: epinephrine and intravenous needle (Drug)
Phase: Phase 2
Status: Completed
Sponsored by: University of Oslo Official(s) and/or principal investigator(s):
Lars Wik, MD, PhD, Principal Investigator, Affiliation: Ullevaal University Hospital
Summary
Intravenous epinephrine has been part of the guidelines for cardiopulmonary resuscitation
since the start. It improves outcome in animal studies, but has never been investigated in a
controlled study in humans. Epidemiologic data indicate that it is an independent negative
predictor for survival. If this is true in a controlled randomized study, it could be due to
effects of the drug itself or more likely due to reduced quality of chest compressions and
ventilations due to the time spent on placing an I. V. needle and injecting drugs.
Clinical Details
Official title: Effects of Epinephrine and I.V. Needle on CPR Outcome
Study design: Treatment, Randomized, Open Label, Placebo Control, Parallel Assignment, Safety/Efficacy Study
Primary outcome: survival to hospital discharge with neurologic outcome
Secondary outcome: admit to hospital with spontaneous circulationone year survival with neurologic outcome
Detailed description:
In a randomized, controlled study of all out-of-hospital cardiac arrest patients in Oslo,
Norway, half the patients are treated according to the international guidelines for advanced
CPR, and the other half according to the same guidelines, except for no I. V. needle or drugs
are given until 5 minutes after eventual return of spontaneous circulation.
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Cardiac arrest out-of-hospital
Exclusion Criteria:
- <18 years old
- Trauma as cause of arrest
Locations and Contacts
Ulleval University Hospital, Oslo N-0407, Norway
Additional Information
Related publications: Holmberg M, Holmberg S, Herlitz J. Low chance of survival among patients requiring adrenaline (epinephrine) or intubation after out-of-hospital cardiac arrest in Sweden. Resuscitation. 2002 Jul;54(1):37-45.
Starting date: January 2003
Ending date: June 2008
Last updated: June 11, 2008
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