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Trigeminal Endonasal Perception: A Predictor for Septoplasty Outcome

Information source: University of Zurich
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Empty Nose Syndrome

Intervention: Nasal surgery (Procedure)

Phase: N/A

Status: Recruiting

Sponsored by: University of Zurich

Official(s) and/or principal investigator(s):
Michael Soyka, Dr.med., Principal Investigator, Affiliation: Zurich University Hospital


This study investigates wether patients with increased trigeminal perception threshold and low expression of TRP channels have more often nasal blockage despite functionally successful nasal surgery (TRP channel = transient receptor potential channel).

Clinical Details

Official title: Trigeminale Endonasale Perzeption, Ein Prädiktor für Das Outcome Einer Septumplastik - Eine Prospektive Kohortenstudie Mit Klinischen Und Biologischen Untersuchungen

Study design: Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention

Primary outcome: Measurement of subjective nasal breathing impairment after surgery depending on trigeminal perception threshold and TRP channel expression

Secondary outcome: Differences between trigeminal perception threshold as as well as TRP expression levels in patients with postoperative empty nose syndrome and patients with subjectively unimpaired nasal breathing after extended intranasal surgery

Detailed description: The aim of this study is to find out wether patients with high trigeminal perception threshold (=decreased intranasal sensibility) and low expression of TRP channels of the mucosa suffer more often from impaired nasal breathing after surgery. This could lead to the identification of prognostic factors and therefore prevention of nasal surgery with bad outcome. Further, differences between patients with empty nose syndrome and asymptomatic patients after extended intranasal surgery, concerning trigeminal perception and TRP channel expression will be investigated.


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- Patients undergoing a primary septoplasty and/or turbinoplasty

- Patients suffering from empty nose syndrome after measurably successful nasal surgery

- Patients with removed turbinates and/or septum, not suffering from ENS (i. e. tumor

patients) Exclusion Criteria:

- Patients with known neurologic disorders that could compromise perception threshold


- Patients with known allergies/intolerance to test agents that are used to measure

perception thresholds (Cineol=Eucalypt; Menthol, CO2= Carbon Dioxide)

- Inability to judge or understand the testing or the informed consent

Locations and Contacts

Zurich University Hospital, Zurich 8091, Switzerland; Recruiting
Michael Soyka, Dr.med., Phone: +41 44 255 11 11, Email: michael.soyka@usz.ch
Michael Soyka, Dr.med., Principal Investigator
Additional Information

Starting date: May 2015
Last updated: June 2, 2015

Page last updated: August 23, 2015

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