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Effect of Carnitine Deficiency on Myocardial Function in Children Receiving Continuous Renal Replacement Therapy

Information source: Children's Research Institute
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Acute Renal Failure

Intervention: Carnitine (Drug)

Phase: Phase 4

Status: Recruiting

Sponsored by: Asha Moudgil

Official(s) and/or principal investigator(s):
Asha Moudgil, MD, Principal Investigator, Affiliation: Children's Research Institute

Overall contact:
Asha Moudgil, MD, Email: amoudgil@cnmc.org

Summary

Carnitine is a nutrient that is usually obtained from the diet, and it is needed for providing energy to the heart and the other muscles in the body. Carnitine is often given to adults and children with kidney failure who receive chronic dialysis three times a week, however there is no published information on how carnitine affects children receiving continuous dialysis (CRRT). We hypothesize that children receiving CRRT quickly become deficient in carnitine because it is continuously removed during dialysis. The aim of this study to determine if giving daily carnitine to children on CRRT will help improve their cardiac function, as assessed by echocardiography, in comparison to a control group.

Clinical Details

Official title: Assessment of the Effect of Carnitine Deficiency on Myocardial Function in Children Receiving Continuous Renal Replacement Therapy

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Cardiac function of children receiving carnitine compared with controls during CRRT

Secondary outcome: Prevalence of carnitine deficiency in children receiving CRRT

Eligibility

Minimum age: 1 Year. Maximum age: 17 Years. Gender(s): Both.

Criteria:

Inclusion Criteria: 1. Children between 1-17 years of age 2. Receiving CRRT at Children's National Medical Center Exclusion Criteria: 1. On chronic dialysis 2. Cardiothoracic surgery within past 14 days 3. Congenital heart disease 4. On carnitine supplementation for a metabolic disorder 5. On CRRT for < 1 week

Locations and Contacts

Asha Moudgil, MD, Email: amoudgil@cnmc.org

Children's National Medical Cetner, Washington, District of Columbia 20010, United States; Recruiting
Asha Moudgil, MD, Email: amoudgil@cnmc.org
Asha Moudgil, MD, Principal Investigator
Additional Information

Starting date: December 2014
Last updated: February 25, 2015

Page last updated: August 23, 2015

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