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Myocardial Protection Effect of Simvastatin Undergoing Cardiac Surgery

Information source: Sun Yat-sen University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Congenital Heart Disease; Heart Valve Disease

Intervention: simvastatin (Drug)

Phase: N/A

Status: Recruiting

Sponsored by: Sun Yat-sen University

Official(s) and/or principal investigator(s):
Jing-song Ou, MD,PhD, Principal Investigator, Affiliation: The Frist Affiliated Hospital, Sun Yat-sen University

Overall contact:
Jing-song Ou, MD, PhD, Phone: 8620-87755766, Ext: 8238, Email: oujs2000@yahoo.com

Summary

Statins have been used to low cholesterol to prevent and treat coronary artery diseases. It was also reported that statins could protect endothelial function and cardiac function during coronary artery bypass graft. We recent found simvastatin reduced myocardial injury during noncoronary artery cardiac surgery in single medical center. We further investigate that whether simvastatin can protect myocardium during noncoronary artery cardiac surgery with cardiopulmonary bypass and improve cardiac function with long term use postoperatively in two medical centers.

Clinical Details

Official title: A Study of Simvastatin on Myocardial Protection and Cardiac Function Undergoing Cardiac Surgery With Cardiopulmonary Bypass

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Prevention

Primary outcome: troponin

Secondary outcome: ejection fraction

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- More than 18-year-old,

- Congenital heart disease(not complex),

- Isolated heart valve disease,

Exclusion Criteria:

- Coronary artery disease

- Allergy for statins

- Poor liver function,Hepatitis

- Gestation women and Breast-feeding women

Locations and Contacts

Jing-song Ou, MD, PhD, Phone: 8620-87755766, Ext: 8238, Email: oujs2000@yahoo.com

The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China; Recruiting
Cong-zhi Rao, MD, Phone: 87333122, Email: raoczh@mail.sysu.edu.cn
Jing-song Ou, MD,PhD, Principal Investigator
Additional Information

Starting date: January 2013
Last updated: March 13, 2015

Page last updated: August 23, 2015

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