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Effect of Aqueous Extract of Garlic and Nystatin Mouthwash in Denture Stomatitis

Information source: Qazvin University Of Medical Sciences
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Denture Stomatitis

Intervention: garlic , nystatin (Drug)

Phase: Phase 2

Status: Completed

Sponsored by: Qazvin University Of Medical Sciences

Official(s) and/or principal investigator(s):
mahin bakhshi, DDS,MS, Study Chair, Affiliation: Qazvin University of Medical Science
Jamileh bigom Taheri, DDS/MS, Study Director, Affiliation: Shahid Beheshti University of Medical Science
Samira Basir Shabestari, DDS/MS, Principal Investigator, Affiliation: QUMS
Rozbeh Pahlevan, DDS, Principal Investigator, Affiliation: QUMS
Anet Tanic, DDS, Principal Investigator, Affiliation: QUMS


The aim of the present study was to compare the effect of aqueous extract of garlic with nystatin mouthwash in denture stomatitis.

Clinical Details

Official title: Comparison of Therapeutic Effect of Aqueous Extract of Garlic and Nystatin Mouthwash in Denture Stomatitis

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Primary outcome: reduction of diameter of erythematous lesion under denture

Secondary outcome: complete relief of erythematous lesions

Detailed description: Denture stomatitis is the most common form of chronic oral candidiasis manifested as chronic inflammation of the mucous membrane t supporting the movable prosthesis that may have a local or systemic nature. This inflammation is presented as mucous erythema and occasionally with pain and burning. The standard treatment for denture stomatitis is administration of nystatin which is accompanied with complications such as bitter taste as well as the high number of drug application that result in reduced tendency of patients in using this medication hence, efforts are continuously being made to substitute other types of therapies for this condition.


Minimum age: 40 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- 40 years of age and older

- confirm of denture stomatitis by the oral medicine specialists

Exclusion Criteria:

- Patients with a history of using anti-fungal drugs, antibiotics, and

corticosteroid within the previous month

- allergy to garlic and nystatin mouthwash

- immunodeficiency

- uncontrolled diabetes

- those with garlic rich diet

- inability in using mouthwash

- loose and discolored dentures

- psychologic disorder and alzheimer

Locations and Contacts

QUMS, Qazvin, Iran, Islamic Republic of
Additional Information

Starting date: July 2010
Last updated: October 15, 2010

Page last updated: August 23, 2015

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