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Metabolomic Fingerprint After Bariatric Surgery

Information source: eSwiss Medical & Surgical Center
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Obesity

Intervention: bariatric surgery (sleeve resection, proximal RYGB, distal RYGB) (Procedure)

Phase: N/A

Status: Completed

Sponsored by: eSwiss Medical & Surgical Center


Background: Obesity is associated with multiple diseases. Bariatric surgery is the most effective therapy for severe obesity that cannot only reduce body weight but also obesity-associated morbidity. Objective: The metabolic alterations associated with obesity and respective changes after bariatric surgery are incompletely understood. Design: In the longitudinal observational study, the investigator applied a 1H-NMR-based global, untargeted metabolomics strategy on human serum samples that were collected before and repeatedly up to one year after distinct bariatric procedures (sleeve gastrectomy, proximal and distal Roux-en Y gastric bypass; RYGB). For comparison, the investigator also analyzed serum samples from normal-weight and less obesity obese subjects that were matched for 1-year postoperative BMI values of the surgical groups.

Clinical Details

Official title: Metabolomic Fingerprint of Severe Obesity is Dynamically Affected by Bariatric Surgery in a Procedure-dependent Manner

Study design: Observational Model: Case Control, Time Perspective: Retrospective

Primary outcome:

compare the NMR metabolic fingerprint as assessed in serum samples of severely obese patients with that of normal-weight control subjects

follow up changes in the metabolic fingerprint over one year after 3 distinct bariatric procedures

compare the metabolic fingerprints established one year after the different surgeries with those of BMI-matched and normal-weight control subjects


Minimum age: 18 Years. Maximum age: 70 Years. Gender(s): Both.


Inclusion Criteria:

- BMI >/=35 kg/m2

- at least 2 years of unsuccessful conservative weight loss attempts

Exclusion Criteria:

- < 18 years of age

- BMI < 35 kg/m2

- informed consent was not signed by the patient

Locations and Contacts

Additional Information

Starting date: May 2010
Last updated: June 24, 2015

Page last updated: August 20, 2015

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