Metabolomic Fingerprint After Bariatric Surgery
Information source: eSwiss Medical & Surgical Center
ClinicalTrials.gov processed this data on August 20, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Obesity
Intervention: bariatric surgery (sleeve resection, proximal RYGB, distal RYGB) (Procedure)
Phase: N/A
Status: Completed
Sponsored by: eSwiss Medical & Surgical Center
Summary
Background: Obesity is associated with multiple diseases. Bariatric surgery is the most
effective therapy for severe obesity that cannot only reduce body weight but also
obesity-associated morbidity.
Objective: The metabolic alterations associated with obesity and respective changes after
bariatric surgery are incompletely understood.
Design: In the longitudinal observational study, the investigator applied a 1H-NMR-based
global, untargeted metabolomics strategy on human serum samples that were collected before
and repeatedly up to one year after distinct bariatric procedures (sleeve gastrectomy,
proximal and distal Roux-en Y gastric bypass; RYGB). For comparison, the investigator also
analyzed serum samples from normal-weight and less obesity obese subjects that were matched
for 1-year postoperative BMI values of the surgical groups.
Clinical Details
Official title: Metabolomic Fingerprint of Severe Obesity is Dynamically Affected by Bariatric Surgery in a Procedure-dependent Manner
Study design: Observational Model: Case Control, Time Perspective: Retrospective
Primary outcome: compare the NMR metabolic fingerprint as assessed in serum samples of severely obese patients with that of normal-weight control subjectsfollow up changes in the metabolic fingerprint over one year after 3 distinct bariatric procedures compare the metabolic fingerprints established one year after the different surgeries with those of BMI-matched and normal-weight control subjects
Eligibility
Minimum age: 18 Years.
Maximum age: 70 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- BMI >/=35 kg/m2
- at least 2 years of unsuccessful conservative weight loss attempts
Exclusion Criteria:
- < 18 years of age
- BMI < 35 kg/m2
- informed consent was not signed by the patient
Locations and Contacts
Additional Information
Starting date: May 2010
Last updated: June 24, 2015
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