Brain Mechanisms Underlying the Effect of the Motilin Receptor Agonist Erythromycin on Hunger in Normal Weight Subjects

Condition(s) targeted: Healthy Volunteers

Intervention: Erythromycin (Drug); Placebo (Drug)

Phase: Phase 4

Status: Not yet recruiting

Sponsored by: Universitaire Ziekenhuizen Leuven

Official(s) and/or principal investigator(s):
Jan Tack, Principal Investigator, Affiliation: University of Leuven

The purpose of this study is to investigate the role of erythromycin, a prokinetic agent, on hunger, and the brain mechanism lying behind it.

Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science

Primary outcome: Functional brain images

Secondary outcome:

hunger scores

gut hormones

Minimum age: 18 Years. Maximum age: 60 Years. Gender(s): Female.

Criteria:

Inclusion Criteria:

- Female only.

- Age > 18 and < 60.

- Body Mass Index (BMI) of 19-25 kg/m2 (no weight change of more than 5 kg in the past

three months).

- Not known to have any chronic medical illness or illnesses affecting the

gastrointestinal, cardiovascular, or nervous systems, chronic pain or psychiatric disorder.

- If female not known to be pregnant.

- Not known to have any past upper gastrointestinal surgery.

Exclusion Criteria:

- Alcohol consumption > 7 drinks / week

- Major depression and chronic health conditions except controlled hypertension

Starting date: September 2014
Last updated: August 8, 2014