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Topical Steroid Treatment After Posterior Lamellar Corneal Transplantation

Information source: Aarhus University Hospital
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Endothelial Dystrophy; Secondary Bullous Keratopathy; Posterior Lamellar Keratoplasty; Descemet's Stripping Endothelial Keratoplasty

Intervention: Weak steroid (Flurolon, Allergan) (Drug); Potent steroid (Maxidex, Alcon) (Drug)

Phase: N/A

Status: Withdrawn

Sponsored by: Aarhus University Hospital

Summary

After corneal transplantation, topical corticosteroids are used to reduce the risk of rejection. However, the optimal postoperative treatment regimen is unknown. In most cases, a topical steroid is administered for at least 6 months after surgery, but it remains to be determined whether potent steroids offer better protection than weak steroids. Also, the length of the treatment is debated. Since the use of steroids is not without potential serious ocular side effects, it is of considerable importance to investigate these problems. The study aims to examine the frequency of rejection episodes after posterior lamellar keratoplasty; specifically comparing a short course of potent steroids versus a long course of weak steroids.

Clinical Details

Official title: Investigation of Treatment With Topical Corticosteroid After Posterior Lamellar Corneal Transplantation

Study design: Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Freedom from rejection

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Patients treated for primary or secondary corneal endothelial failure at the

department of ophthalmology, Aarhus University Hospital Exclusion Criteria:

- Not fulfilling the above

Locations and Contacts

Department of Ophthalmology, Aarhus Universtity Hospital, Aarhus DK-8000, Denmark
Additional Information

Starting date: September 2012
Last updated: April 30, 2014

Page last updated: August 23, 2015

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