Topical Steroid Treatment After Posterior Lamellar Corneal Transplantation
Information source: Aarhus University Hospital
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Endothelial Dystrophy; Secondary Bullous Keratopathy; Posterior Lamellar Keratoplasty; Descemet's Stripping Endothelial Keratoplasty
Intervention: Weak steroid (Flurolon, Allergan) (Drug); Potent steroid (Maxidex, Alcon) (Drug)
Phase: N/A
Status: Withdrawn
Sponsored by: Aarhus University Hospital
Summary
After corneal transplantation, topical corticosteroids are used to reduce the risk of
rejection.
However, the optimal postoperative treatment regimen is unknown. In most cases, a topical
steroid is administered for at least 6 months after surgery, but it remains to be determined
whether potent steroids offer better protection than weak steroids. Also, the length of the
treatment is debated.
Since the use of steroids is not without potential serious ocular side effects, it is of
considerable importance to investigate these problems.
The study aims to examine the frequency of rejection episodes after posterior lamellar
keratoplasty; specifically comparing a short course of potent steroids versus a long course
of weak steroids.
Clinical Details
Official title: Investigation of Treatment With Topical Corticosteroid After Posterior Lamellar Corneal Transplantation
Study design: Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Primary outcome: Freedom from rejection
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Patients treated for primary or secondary corneal endothelial failure at the
department of ophthalmology, Aarhus University Hospital
Exclusion Criteria:
- Not fulfilling the above
Locations and Contacts
Department of Ophthalmology, Aarhus Universtity Hospital, Aarhus DK-8000, Denmark
Additional Information
Starting date: September 2012
Last updated: April 30, 2014
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