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Study of TRC105 Combined With Standard-Dose Bevacizumab for Advanced Solid Tumors for Which Bevacizumab is Indicated

Information source: Tracon Pharmaceuticals Inc.
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Adult Solid Tumor

Intervention: TRC105 and Bevacizumab (Drug)

Phase: Phase 1

Status: Completed

Sponsored by: Tracon Pharmaceuticals Inc.

Official(s) and/or principal investigator(s):
Charles P Theuer, MD, Study Director, Affiliation: Tracon Pharmaceuticals Inc.

Summary

The purpose of the study is to evaluate safety and tolerability and determine a recommended Phase 2 dose for TRC105 when added to standard dose bevacizumab in patients with advanced solid tumors for which bevacizumab is indicated.

Clinical Details

Official title: An Open Label Phase 1B Dose-Escalation Study of TRC105 Combined With Standard-Dose Bevacizumab for Advanced Solid Tumors

Study design: Allocation: Non-Randomized, Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Determine Maximum Tolerated Dose of TRC105 in Combination With Bevacizumab

Secondary outcome:

TRC105 Pharmacokinetic Concentrations

Immune Response to TRC105

Objective Response According to RECIST 1.1

Detailed description: Bevacizumab is a monoclonal antibody to vascular endothelial growth factor (VEGF) that inhibits angiogenesis and extends survival in patients with a wide variety of solid tumor types. TRC105, a monoclonal antibody to CD105, is a novel angiogenesis inhibitor that complements bevacizumab in preclinical models. Together, these antibodies may result in more effective angiogenesis inhibition and improved clinical efficacy over that seen with bevacizumab alone. The purpose of the study is to evaluate safety and tolerability and determine a recommended Phase 2 dose for TRC105 when added to standard dose bevacizumab in patients with advanced solid tumors for which bevacizumab is indicated.

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria: 1. Histologically proven advanced or metastatic solid cancer 2. Measurable disease, evaluable disease or elevation of a relevant soluble tumor marker (e. g., CEA, PSA, CA125) 3. Age of 18 years or older 4. ECOG performance status of 0 or 1 5. Resolution of all acute AEs resulting from prior cancer therapies to NCI CTCAE Grade ≤ 1 or baseline (except alopecia) 6. Adequate organ function 7. Willing and able to consent for self to participate in study Exclusion Criteria: 1. Prior treatment with TRC105 2. Serious dose-limiting toxicity related to prior bevacizumab 3. Current treatment on another therapeutic clinical trial 4. Receipt of an investigational agent within 28 days of starting study treatment 5. Prior surgery (including open biopsy) within 28 days of starting the study treatment 6. Prior radiation therapy or systemic therapy within 21 days of starting the study treatment 7. Minor surgical procedures such as fine needle aspirations, Mediport placement or core biopsies within 7 days of study treatment 8. Uncontrolled chronic hypertension defined as systolic > 140 or diastolic > 90 despite optimal therapy (initiation or adjustment of BP medication prior to study entry allowed provided that the average of 3 BP readings at a visit prior to enrollment is < 140/90 mm Hg) 9. Symptomatic pericardial or pleural effusions 10. Uncontrolled peritoneal effusions requiring paracentesis more frequently than every 2 weeks 11. History of brain involvement with cancer, spinal cord compression, or carcinomatous meningitis, or new evidence of brain or leptomeningeal disease (except in the expansion cohort at the MTD where brain metastases or primary brain tumors are eligible) 12. Angina, MI, symptomatic congestive heart failure, cerebrovascular accident, transient ischemic attack, arterial embolism, pulmonary embolism, DVT, PTCA or CABG within the past 6 months 13. Active bleeding or pathologic condition that carries a high risk of bleeding 14. Thrombolytic or anticoagulant use (except to maintain i. v. catheters) within 10 days prior to first day of study therapy 15. Cardiac dysrhythmias of NCI CTCAE Grade ≥ 2 within the last 28 days 16. Known active viral or nonviral hepatitis 17. Centrally located non-small cell lung cancer (regardless of histologic sub-type), or non-small cell lung cancer of squamous histology. 18. History of hemorrhage or hemoptysis (>½ teaspoon bright red blood) within 6 months of starting study treatment 19. Open wounds or unhealed fractures within 28 days of starting study treatment 20. History of peptic ulcer disease or erosive gastritis within the past 6 months, unless treated for the condition and complete resolution has been documented by esophagogastroduodenoscopy (EGD) within 28 days of starting study treatment 21. Known human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) related illness 22. Pregnancy or breastfeeding

Locations and Contacts

University of Alabama at Birmingham, Birmingham, Alabama 35249, United States

Pinnacle Oncology Hematology, Scottsdale, Arizona 85258, United States

UCLA Hematology and Oncology, Santa Monica, California 90404, United States

Indiana University Simon Cancer Center, Indianapolis, Indiana 46202, United States

Additional Information

Starting date: April 2011
Last updated: February 12, 2014

Page last updated: August 20, 2015

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