DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Endoscopic Band Ligation (EBL) Versus Endoscopic Band Ligation and Propranolol for the Prevention of Variceal Rebleeding

Information source: Korea University
Information obtained from ClinicalTrials.gov on October 19, 2009
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Cirrhosis; Variceal Bleeding

Intervention: endoscopic band ligation (Procedure); EBL+Propranolol (Procedure)

Phase: Phase 4

Status: Recruiting

Sponsored by: Korea University

Overall contact:
Soon Ho Um, Prof, Phone: 82-2-920-5019, Email: umsh@korea.ac.kr


Both propranolol and endoscopic band ligation (EBL) are effective for prevention of variceal rebleeding. Recently several studies compared the efficacy of EBL alone and with a combination of propranolol and EBL. However, the results of recent studies showed discrepancy. This study is performed to compare the efficacy and safety of EBL alone and EBL combined with propranolol in patients without previous history of endoscopic variceal treatment.

Clinical Details

Official title: RCT Comparing the Efficacies of Endoscopic Variceal Ligation (EBL) and Combined Treatment of Beta-blocker and EBL for the Prevention of Esophageal Variceal Rebleeding

Study design: Prevention, Randomized, Open Label, Active Control, Parallel Assignment, Safety/Efficacy Study

Primary outcome: Rebleeding from esophageal varices

Secondary outcome: Upper gastrointestinal bleeding; significant esophageal variceal bleeding; mortality;adverse events


Minimum age: 18 Years. Maximum age: 70 Years. Gender(s): Both.


Inclusion Criteria:

- liver cirrhosis

- age between 18 and 70 years

- Successful control of esophageal variceal bleeding within 6 weeks before enrollment

Exclusion Criteria:

- Gastric variceal bleeding

- Patients with systolic blood pressure <100 mmHg or basal heart rate <60/min

- Portal vein thrombosis

- Prominent hepatic encephalopathy

- Coexisting untreated malignancy

- Severe cerebrovascular or cardiovascular disease, renal failure

- Previous history of endoscopic, radiologic, or surgical treatment for varices or


- Contraindication to beta-blocker

- Pregnancy

- Refusal to give consent to participate in the trial

Locations and Contacts

Soon Ho Um, Prof, Phone: 82-2-920-5019, Email: umsh@korea.ac.kr

Korea University Anam Hospital, Seoul 136-705, Korea, Republic of; Recruiting
Additional Information

Starting date: August 2008
Ending date: July 2013
Last updated: August 25, 2009

Page last updated: October 19, 2009

-- advertisement -- The American Red Cross
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2015