The primary purpose of this study is to determine if duloxetine reduces pain severity in
patients with osteoarthritis knee pain.
Patient Global Impression of Improvement at 13 Week EndpointChange From Baseline to 13 Week Endpoint in Western Ontario and McMaster Osteoarthritis Index (WOMAC) - Pain Subscale
Change From Baseline to 13 Week Endpoint in Western Ontario and McMaster Osteoarthritis Index (WOMAC) - Stiffness Subscale
Change From Baseline to 13 Week Endpoint in Western Ontario and McMaster Osteoarthritis Index (WOMAC) - Physical Function Subscale
Change From Baseline to 13 Week Endpoint in Western Ontario and McMaster Osteoarthritis Index (WOMAC) - Total Score
Change From Baseline to 13 Week Endpoint in Weekly Mean of the 24-Hour Worst Pain Score
Weekly Change From Baseline in the 24-Hour Worst Pain Score
Change From Baseline to 13 Week Endpoint in Weekly Mean of 24-Hour Average Pain in the Re-Randomized Treatment Phase
Change From Baseline to 13 Week Endpoint in Clinical Global Impression of Severity
Change From Baseline to 13 Week Endpoint in Brief Pain Inventory (BPI) - Worst Pain Score
Change From Baseline to 13 Week Endpoint in Brief Pain Inventory - Least Pain Score
Change From Baseline to 13 Week Endpoint in Brief Pain Inventory - Average Pain Score
Change From Baseline to 13 Week Endpoint in Brief Pain Inventory - Pain Right Now Score
Change From Baseline to 13 Week Endpoint in Brief Pain Inventory Interference Score - General Activity
Change From Baseline to 13 Week Endpoint in Brief Pain Inventory Interference Score - Mood
Change From Baseline to 13 Week Endpoint in Brief Pain Inventory Interference Score - Walking Ability
Change From Baseline to 13 Week Endpoint in Brief Pain Inventory Interference Score - Normal Work
Change From Baseline to 13 Week Endpoint in Brief Pain Inventory Interference Score - Relations With Other People
Change From Baseline to 13 Week Endpoint in Brief Pain Inventory Interference Score - Sleep
Change From Baseline to 13 Week Endpoint in Brief Pain Inventory Interference Score - Enjoyment of Life
Change From Baseline to 13 Week Endpoint in Brief Pain Inventory Average Interference
Response to Treatment - The Number of Participants With a >= 30% Reduction of Weekly Mean in 24-Hour Average Pain Severity Ratings
Response to Treatment - The Number of Participants With a >=30% Reduction of Weekly Mean in 24-Hour Average Pain Severity Ratings in the Re-Randomized Treatment Phase
Change From Baseline to 13 Week Endpoint in Medical Outcomes Study Short Form-36 (SF-36) - Mental Health Component Summary
Change From Baseline to 13 Week Endpoint in Medical Outcomes Study Short Form-36 (SF-36) - Physical Component Summary
Change From Baseline to 13 Week Endpoint in Euro-Quality of Life - 5 Dimensions (EQ-5D): US Based Index Score
Change From Baseline to 13 Week Endpoint in Beck Depression Inventory-II - Total Score
Change From Baseline to 13 Week Endpoint in Hospital Anxiety and Depression Scale (HADS) - Anxiety Subscale
Statistically Significant Change From Baseline to 13 Week Endpoint in Laboratory Data - Chemistry Analytes: Alkaline Phosphatase
Statistically Significant Change From Baseline to 13 Week Endpoint in Laboratory Data - Chemistry Analytes: Uric Acid
Change From Baseline to 13 Week Endpoint in Vital Signs - Pulse Rate
Change From Baseline to 13 Week Endpoint in Vital Signs - Blood Pressure (BP) Diastolic
Change From Baseline to 13 Week Endpoint in Vital Signs - Blood Pressure (BP) Systolic
Change From Baseline to 13 Week Endpoint in Vital Signs - Weight
Minimum age: 40 Years.
Maximum age: N/A.
Gender(s): Both.
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