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The Application of Target Controlled Infusion of Etomidate Combined With Propofol in the Maintenance of Anesthesia During Brain Surgeries

Information source: Henan Provincial Hospital
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Target Controlled Infusion; General Anesthesia

Intervention: propofol (Drug); etomidate (Drug)

Phase: Phase 4

Status: Not yet recruiting

Sponsored by: Henan Provincial Hospital

Summary

To explore the application of target controlled infusion of etomidate combined with propofol in the maintenance of anesthesia during brain surgeries.

Clinical Details

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Primary outcome:

Heart rate

Blood pressure

Concentration of cortisol

Secondary outcome:

Use of vasoactive agent

The time from stop of remifentanil to awake

Severity of agitation

Postoperative nausea and vomiting

Dose of etomidate and propofol

Intraoperative awareness

Expense of anesthetics

Allergic reaction

Eligibility

Minimum age: 18 Years. Maximum age: 60 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Aged between 60 and 80 years Brain surgeries Body weight is between 45 to 75 kg and

body mass index is no more than 30 kg/m2 American Society of Anesthesiology (ASA) Physical Status: Ⅰ or Ⅱ Expected operation duration is between 3 and 5 h Signed informed consent form Exclusion Criteria:

- Serious cardiac, cerebral(acute stroke, uncontrolled seizure, sever dementia), liver,

kidney, lung, endocrine disease or sepsis History of general anesthesia within 24 h before the operation Long use of hormone or history of adrenal suppression Hyperlipidaemia Long use of psychotropic substances Systolic pressure is still under 90 mm Hg after twice given of vasopressor agent Suspected abuse of narcotic analgesia Patients need to use neuromuscular blocking drugs (except intubation) Allergy to trial drug or other contraindication Pregnant or breast-feeding women Attendance of other trial past 30 days

Locations and Contacts

Additional Information

Starting date: October 2014
Last updated: June 24, 2014

Page last updated: August 20, 2015

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