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Cabergoline and Coasting to Prevent OHSS

Information source: Cairo University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: OHSS

Intervention: ICSI (Procedure)

Phase: Phase 3

Status: Completed

Sponsored by: Cairo University

Official(s) and/or principal investigator(s):
Mohamed Roushdy, MD, Study Chair, Affiliation: Cairo University

Summary

The effectiveness of cabergoline to prevent moderate-severe OHSS to coasting.

Clinical Details

Official title: Combining Cabergoline and Coasting in Gonadotropin Releasing Hormone(GnRH)Agonist Protocol in Intracytoplasmic Sperm Injection (ICSI) to Prevent Ovarian Hyperstimulation Syndrome (OHSS): a Randomized Clinical Trial

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention

Primary outcome: Rate and degree of OHSS (composite outcome)

Secondary outcome: Number of oocytes

Detailed description: To randomly compare three study groups under a high risk of developing OHSS to one of three arms of management, either coasting for 1 to 3 days or receiving cabergoline for 8 days or coasting for 1 day plus receiving cabergoline for 8 days in ICSI patients following the long luteal GnRH agonist protocol.

Eligibility

Minimum age: 20 Years. Maximum age: 35 Years. Gender(s): Female.

Criteria:

Inclusion Criteria: 1. Age or= 3500 pg/ml 4. Retrieving more than 15 oocytes Exclusion Criteria: 1. Male factor 2. Uterine factor

Locations and Contacts

IVF centre, Obstetrics and Gynaecology Department, Cairo University Hospitals (Kasr EL Aini), Cairo, Egypt
Additional Information

Related publications:

Esinler I, Bozdag G, Karakocsokmensuer L. Preventing ovarian hyperstimulation syndrome: cabergoline versus coasting. Arch Gynecol Obstet. 2013 Nov;288(5):1159-63. doi: 10.1007/s00404-013-2875-z. Epub 2013 May 16.

Starting date: October 2013
Last updated: August 5, 2015

Page last updated: August 23, 2015

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