A Study Evaluating the Efficacy and Safety of ARTISS Human Fibrin Sealant as Used in External Rhinoplasty
Information source: DeNova Research
ClinicalTrials.gov processed this data on August 20, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Rhinoplasty
Intervention: ARTISS human fibrin sealant (Biological)
Phase: Phase 2
Status: Recruiting
Sponsored by: DeNova Research Official(s) and/or principal investigator(s): Steven H Dayan, MD, Principal Investigator, Affiliation: DeNova Research
Overall contact: Katherine Cho, MPH, Phone: 312.335.2070, Email: katherine@denovaresearch.com
Summary
Rhinoplasty (nasal reconstruction i. e. "a nose job") is a surgical procedure performed on
the nose to correct a medical problem or change the appearance of the nose. During the
healing process, swelling and/or bruising is likely to occur. A drug called ARTISS Fibrin
Sealant may or may not lessen these effects. This study is looking to see the effects of
ARTISS on adhering tissue and improving wound healing in an external rhinoplasty. The
purpose of this study is to evaluate the safety and effectiveness of rhinoplasty using
ARTISS compared to rhinoplasty without using ARTISS in patients undergoing rhinoplasty
performed through an external approach.
Clinical Details
Official title: A Prospective, Double-Blinded, Randomized Study Evaluating the Efficacy and Safety of ARTISS Human Fibrin Sealant as Used in External Rhinoplasty
Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Treatment
Primary outcome: EfficacyThe primary safety endpoint is the incidence of AEs.
Secondary outcome: Severity of EdemaBlinded-assessment of satisfaction Objective Ecchymosis Evaluation Subjective Ecchymosis Evaluation Number of Participants with Adverse Events Subject Downtime Questionnaire HPSS Assessment Ease of Use
Eligibility
Minimum age: 18 Years.
Maximum age: 65 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
1. Males and females between 18 and 65 years of age.
2. Subjects requesting primary rhinoplasty and requiring an external approach.
3. Subjects willing to undergo treatment with fibrin sealant.
4. Willingness and ability to comply with protocol requirements, including returning for
follow-up visits and abstaining from exclusionary procedures for the duration of the
study.
5. Willingness and ability to comply with the PI's standard preoperative and
postoperative rhinoplasty instructions.
6. Subjects of childbearing potential must have a negative urine pregnancy test result
at Visit 1 and be willing able to use an acceptable method of birth control (e. g.,
barrier methods used with a spermicidal agent, hormonal methods, IUD, surgical
sterilization, abstinence) during the study. Women will not be considered of
childbearing potential if one of the following is documented on the medical history:
- postmenopausal for at least 12 months prior to study drug administration
- without a uterus and/or both ovaries
- has had a bilateral tubal ligation for at least 6 months prior to study drug
administration.
- absence of an other physical condition according to the PI's discretion
7. Willingness and ability to provide written photo consent and adherence to photography
procedures (i. e., removal of jewelry and makeup).
8. Willingness and ability to provide written informed consent prior to performance of
any study related procedure.
Exclusion Criteria:
1. Subjects who are pregnant, nursing, planning to become pregnant, and/or not using a
reliable form of birth control.
2. Subjects who are planning a concurrent facial surgery during the operation (eg
forehead plasty, blepharoplasty, rhinoplasty, buccal fat removal, any filler
injections including fat injections, lip augmentation, skin resurfacing procedures
etc.).
3. Subjects with a previous history of rhinoplasty.
4. Subjects with a current history of smoking.
5. Subjects with a previous history of a bleeding or coagulation disorder .
6. Subject with a previous history of a vascular disorder, cardiovascular disease,
and/or uncontrolled hypertension.
7. Subjects a previous history of diabetes mellitus with glycosylated hemoglobin (HbA1c)
> 7.
8. Subjects undergoing active treatment for a malignancy.
9. Subjects with a previous history of has a connective tissue disorder.
10. Subjects with active or chronic skin disorder.
11. Subjects with a previous history of Bell's palsy.
12. Subjects with a previous history of pathologically or pharmacologically induced
immune deficiency.
13. Subjects who have received chronic treatment with immunosuppressive drugs, systemic
corticosteroids, or other chronic treatments within 30 days prior to the surgery.
14. Subjects with a known sensitivity to components of FS VH S/D 4 s-apr.
15. Subjects with a previous history of healing complications following previous
surgeries (eg, hypertrophic scarring).
16. Subjects with a significant systemic illness or illness localized to the areas of
treatment.
17. Subjects with previous history of nasal implants.
18. Subjects with previous or current history of nasal infections.
19. Subjects who have history of blood thinners (aspirin, ibuprofen, naprosyn, herbal
supplements, Vitamin E) within the two weeks prior to surgery.
20. Subjects who have smoked within the two weeks prior to surgery.
21. Subjects who have had alcohol or illicit drugs one week prior to surgery.
22. Subjects who have eaten or drank anything after midnight the night prior to surgery.
23. Subjects with current history of chronic drug or alcohol abuse.
24. Concurrent therapy that, in the investigator's opinion, would interfere with the
evaluation of the safety or efficacy of the study medication.
25. Subjects who anticipate the need for surgery, other than the study procedure, or
overnight hospitalization during the study.
26. Subjects who, in the Investigator's opinion, have a history of poor cooperation, non
compliance with medical treatment or unreliability.
27. Subject has participated in another clinical study involving an investigational
product/device within 30 days prior to enrollment or is scheduled to participate in
another clinical study involving an investigational product/device during the course
of this study
Locations and Contacts
Katherine Cho, MPH, Phone: 312.335.2070, Email: katherine@denovaresearch.com
DeNova Research, Chicago, Illinois 60611, United States; Recruiting Katherine Cho, MPH, Phone: 312-335-2070, Email: katherine@denovaresearch.com Steven H Dayan, MD, Principal Investigator
Additional Information
Starting date: November 2012
Last updated: September 12, 2014
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