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Bioavailability Study of Propranolol Under Fasting Conditions

Information source: Par Pharmaceutical, Inc.
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: To Determine Bioequivalence Under Fasting Conditions

Intervention: Propranolol (Drug); Inderal-LA (Drug)

Phase: Phase 2

Status: Completed

Sponsored by: Par Pharmaceutical, Inc.

Official(s) and/or principal investigator(s):
Denis Audet, Principal Investigator, Affiliation: SFBC Anapharm

Summary

To compare the single-dose bioavailability of Propranolol 160 Mg ER capsules with Inderal-La

Clinical Details

Official title: Comparative, Randomized, Single-Dose, 2 Way Cross Over Bioavailability Study of Par Propranolol 160 mg With That of Inderal-LA Propranolol 160 mg in Healthy Subjects Under Fasting Conditions.

Study design: Other, Randomized, Open Label, Crossover Assignment

Primary outcome: Rate and Extend of Absorption

Detailed description:

To compare the single - dose bioavailability of Par Propranolol 160 Mg ER capsules with Wyeth

Pharmaceuticals, Inderal-LA, Propranolol under fasting conditions.

Eligibility

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Subjects enrolled in the study will be members of the community at large. The

Recruitment advertisements may use various media types (E. g. ratio, newspapers, SFBC Anapharm Website, SFBC Anapharm volunteer's database). Subjects must meet all the following criteria in order to be included in the study.

- Male and female, non-smoker, 18 years of age and older

- Capable of consent

- BMI ≥ 19. 0 and > 30. 0 kg/ m2.

Exclusion Criteria:

- Subjects to whom any of the following applies will be excluded from the study.

- Clinically significant illness within 4 weeks prior to the administration of the study

medication

- Clinically significant surgery within 4 weeks prior to the administration of the study

medication.

- Any clinically significant abnormality found during medical screening.

- Any reason which, in the opinion of the Medical Sub- Investigator, would prevent the

subject from participating in the study.

- Abnormal laboratory tests judged clinically significant.

- Positive testing for hepatitis B, hepatitis C, or HIV at screening.

- ECG abnormalities (clinically significant) or vital sign abnormalities (systolic blood

pressure lower than 100 or over 140 mmHg, diastolic blood pressure lower than 60 or over 90 mmHg, or heart rate less than 60 or over 100 bpm) at screening.

- History of significant alcohol abuse or drug abuse within one year prior to the

screening visit.

- Regular use of alcohol within six months prior to the screening visit (more than

fourteen units of alcohol per week [ 1 Unit = 150mL of wine, 360 mL of beer, or 45mL of 40% alcohol])

- Use of soft drugs ( such as marijuana) within 3 months prior to the screening visit

or hard drugs (such as cocaine, phencyclidine [PCP] and crack) within 1 year prior to the screening visit or positive urine drug at screening.

- History of allergic reactions to heparin, propranolol, or other related drugs.

- Use of any drugs known to induce or inhibit hepatic drug metabolism (examples of

inducers: barbiturates, carbamazepine, phenytoin,glucocorticoids , omerprazole; examples of inhibitors: antidepressants (SSRI), cimetidine, diltiazem, macrolides, imidazoles, neuroleptics, verapamil, fluoroquinolones, antihistamines) within 30 days prior to administration of the study medication.

- Use of an investigational drug or participation in an investigational study within 30

days prior to administration of the study medication.

- Clinically significant history or presence of any clinically significant

gastrointestinal pathology (e. g. chronic diarrhea, inflammatory bowel diseases), unresolved gastrointestinal symptoms (e. g. diarrhea, vomiting), liver or kidney disease, or other conditions known as interface with the absorption, distribution, metabolism, or excretion of the drug.

- Any clinically significant history or presence of clinically significant neurological,

endocrinal, cardiovascular, pulmonary, hematologic, psychiatric, or metabolic disease.

- Use of prescription medication within 14 days prior to administration of a study

medication or over the counter products (including natural food supplements, vitamins, garlic as a supplement) within 7 days prior to administration of study medication, except for topical products without systemic absorption and hormonal contraceptive.

- Difficulty to swallow study medication.

- Use of any tobacco products in the 6 months proceeding drug administration.

- Any food allergy, intolerance, restriction or special diet that, in the opinion of the

Medical Sub- Investigator, could contraindicate the subject's participation in this study.

- A depot injection or an implant of any drug (other than contraceptives) within 3

months prior to administration of study medication.

- Donation of plasma (500 Ml) within 7 days to drug administration. Donation or loss of

whole blood (excluding the volume of blood drawn during the screening procedures of this study) prior to administration of the study medication as follows.

- 50mL to 300mL of whole blood within 30 days, 301 mL to 500 ml of whole blood within

45days or more than 500 mL of whole blood within 56 days prior to drug administration..

- History bronchial asthma and bronchospastic diseases.

- History of known presence of cardiogenic shock, sinus bradycardia, Wolff-Parkinson

White Syndrome, congestive heart failure or angina.

- Clinically significant history of diabetes.

- Clinically significant history of hyperthyroidism.

- Breast- feeding subject.

- Positive urine pregnancy test at screening.

- Female subjects of childbearing potential having unprotected sexual intercourse with

any non- sterile male partner (i. e. male who ahs not been sterilized by vasectomy for al least 6 months) within 14 days prior to study drug administration. Acceptable methods of contraception:

- Intra-uterine contraceptive device (place al least 4 weeks prior to study drug

administration)

- Condom or diaphragm. + spermicide

- Hormonal contraceptives (starting al least 4 weeks prior to study administration)

Locations and Contacts

SFBC Anapharm, Sainte- Foy, Quebec G1V2K8, Canada
Additional Information

Starting date: May 2005
Ending date: November 2005
Last updated: April 1, 2008

Page last updated: June 20, 2008

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