Interaction of Statins and Nondepolarizing Muscle Relaxants

Condition(s) targeted: Pain

Intervention: Rocuronium (Drug)

Phase: Phase 4

Status: Recruiting

Sponsored by: Huang-wei LV

Official(s) and/or principal investigator(s):
Huangwei Lv, Professor, Study Director, Affiliation: the Anesthesiology Department

provide evidence for prevention or reduction muscle pain.

Official title: Interaction of Statins and Nondepolarizing Muscle Relaxants

Study design: Observational Model: Case Control, Time Perspective: Prospective

Primary outcome: plasma myoglobin concentration

Secondary outcome:

muscle pain

serum potassium concentration

plasma creatine phosphokinase concentration

urine myoglobin and onset plus duration of succinylcholine block

Detailed description: The purpose of this study is to determine interaction of statins and nondepolarizing muscle relaxant,In order to provide evidence for prevention or reduction muscle pain.

Minimum age: 40 Years. Maximum age: 80 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Patients with American Society of Anesthesiologists physical status I-III

- Patients taking statins for at least 3 months and those who had never used statins

were considered to be eligible Exclusion Criteria:

- Orthopedic

- Spinal surgery

- Surgery involving extensive muscle manipulation

- History of liver and kidney failure

- Neuromuscular disease

- Susceptibility to or family history of malignant hyperthermia

- Extensive denervation of skeletal muscle

- Chronic pain syndromes

- Taking medications that might interact with the effect of rocuronium or serum

myoglobin difficult intubation

China Medical University, Shenyang, Liaoning 110001, China; Recruiting
Huang-wei Lv, Professor, Phone: 86-024-83283100, Email: hwl1998@yahoo.com
Huang-wei LV, Professor, Principal Investigator

Starting date: October 2014
Last updated: October 22, 2014