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Respiratory Kinematics of Cough in Healthy Older Adults and Parkinson's Disease

Information source: University of Florida
ClinicalTrials.gov processed this data on August 20, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Cough; Parkinson's Disease

Intervention: Capsaicin (Drug); Healthy Older Adults (Other); Parkinson's Disease (Other)

Phase: Phase 1/Phase 2

Status: Recruiting

Sponsored by: University of Florida

Official(s) and/or principal investigator(s):
Karen W. Hegland, Ph.D., Principal Investigator, Affiliation: University of Florida
Alexandra E. Brandimore, M.A. CCC/SLP, Study Director, Affiliation: University of Florida

Overall contact:
Alexandra E. Brandimore, M.A. CCC/SLP, Phone: 352-273-3711, Email: aessman@ufl.edu

Summary

The purpose of this research study is to test cough function in individuals with Parkinson's disease and healthy older adults. Cough is a complex, defensive function which involves movement of the chest and lungs. The investigators want to compare the movement of the chest wall and the lungs during voluntary and reflex cough. The long-term goal of this research is to develop treatments for people with cough dysfunction. Cough dysfunction increases the risk for respiratory infections such as pneumonia. The results from this study will provide information to help researchers understand the difference between reflex and voluntary cough more fully.

Clinical Details

Official title: Respiratory Kinematics of Reflex and Voluntary Cough in Healthy Older Adults and Parkinson's Disease

Study design: Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome:

Lung volume initiation

Peak expiratory flow rate

Detailed description: If the participant agrees to participate, the investigators will first test pulmonary (lung) function. Next, the investigators will test voluntary and reflex cough. After this first round of cough testing, the investigators will ask participants to cough long and hard during voluntary and reflex cough testing. Finally, the investigators will view the larynx (voice box) with an endoscopic camera inserted through the nose. This test is done to see if there are any changes in the larynx that may influence cough.

Eligibility

Minimum age: 55 Years. Maximum age: 85 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Age 55-85 years

- Ability to provide informed consent

For participants with Parkinson's disease (PD):

- Diagnosis of PD (Hoehn & Yahr stages II-IV) by a University of Florida Movement

Disorders fellowship trained neurologist having completed a clinical assessment of each participant's PD severity and arriving at the diagnosis of PD by applying strict United Kingdom brain bank criteria. Exclusion Criteria: Participants with PD:

- History of neurological disorders other than PD (e. g. multiple sclerosis, stroke, brain

tumor, etc) Healthy older adults:

- History of neurological disease including PD

- History of head and neck cancer

- History of breathing disorders or disease (i. e. chronic obstructive pulmonary

disease, asthma)

- History of smoking for more than 5 years at any one time (as this reduces the

sensitivity to capsaicin)

- History of chest infection the last 5 weeks

- Failure of a screening test of pulmonary function (e. g. forced expiratory volume in

one second/forced vital capacity<75%)

- Difficulty complying due to neuropsychological dysfunction (i. e. severe depression)

Locations and Contacts

Alexandra E. Brandimore, M.A. CCC/SLP, Phone: 352-273-3711, Email: aessman@ufl.edu

Center for Movement Disorders and Neurorestoration, Gainesville, Florida 32611, United States; Recruiting
Alexandra E Brandimore, M.A., Phone: 352-273-3711, Email: aessman@ufl.edu
Alexandra E Brandimore, MA, Sub-Investigator

Dauer Hall, University of Florida, Gainesville, Florida 32611, United States; Recruiting
Alexandra E Brandimore, MA, Phone: 352-273-3711, Email: aessman@ufl.edu
Alexandra E Brandimore, MA, Sub-Investigator

Additional Information

Related publications:

Smith JA, Aliverti A, Quaranta M, McGuinness K, Kelsall A, Earis J, Calverley PM. Chest wall dynamics during voluntary and induced cough in healthy volunteers. J Physiol. 2012 Feb 1;590(Pt 3):563-74. doi: 10.1113/jphysiol.2011.213157. Epub 2011 Dec 5.

Starting date: October 2014
Last updated: February 24, 2015

Page last updated: August 20, 2015

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