The Cognitive Effects of Lorazepam in Healthy Older Individuals With TOMM40 Variable-length Polymorphisms
Information source: Mayo Clinic
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Alzheimer's Disease (AD)
Intervention: lorazepam (Drug)
Phase: Phase 1
Status: Recruiting
Sponsored by: Mayo Clinic Official(s) and/or principal investigator(s): Cynthia Stonnington, MD, Principal Investigator, Affiliation: Mayo Clinic
Overall contact: Jan A Light, LPN, Phone: (480) 301-8788, Email: Light.Jan@mayo.edu
Summary
The investigators' goal is to determine if certain tests of memory and attention, performed
while sleepiness is induced by a single dose of lorazepam, can predict whether or not an
individual is at risk for developing Alzheimer's disease.
Clinical Details
Official title: The Cognitive Effects of Lorazepam in Healthy Older Individuals With TOMM40 Variable-length Polymorphisms
Study design: Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Basic Science
Primary outcome: AVLT Long term memory scoreGroton Maze Learning Test (GMLT) score
Eligibility
Minimum age: 50 Years.
Maximum age: 80 Years.
Gender(s): Both.
Criteria:
Inclusion criteria:
- MMSE score of 28-30
- Hamilton Depression Rating Scale score of less than 10
- participants in longitudinal study of aging and have a TOMM40 genotype of S/S, VL/VL,
S/VL, L/S or L/VL.
Exclusion criteria:
- Alzheimer's Disease or Mild Cognitive Impairment
- any significant medical, psychiatric, and neurological illnesses, e. g., impaired
liver or kidney function, prior stroke, traumatic brain injury, memory impairment,
cognitive impairment, parkinsonism, a lifetime history of schizophrenia, bipolar
disorder, a psychoactive substance use disorder, or current major depression.
- known allergy to benzodiazepines
- current use (within the previous four weeks) of benzodiazepines or other medications
known to interact with lorazepam, current use of sedating antihistamines, or current
use of stimulant medications
Locations and Contacts
Jan A Light, LPN, Phone: (480) 301-8788, Email: Light.Jan@mayo.edu
Mayo Clinic, Scottsdale, Arizona 85259, United States; Recruiting
Additional Information
Starting date: January 2013
Last updated: April 10, 2015
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