DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Use of Erythromycin in Mustard-Induced Bronchiolitis

Information source: Baqiyatallah Medical Sciences University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Bronchiolitis Obliterans; Acute Obliterating Bronchiolitis

Intervention: Erythromycin (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Baqiyatallah Medical Sciences University

Official(s) and/or principal investigator(s):
Mostafa Ghanei, Professor, Study Director, Affiliation: Research Center of Chemical Injuries, Baqyatallah Medical Sciences University, Tehran, Iran


We looked for the effectiveness of low-dose long-term prescription of erythromycin in mustard-induced bronchiolitis obliterans

Clinical Details

Official title: Low-Dose Long-Term Prescription of Erythromycin in Mustard-Induced Bronchiolitis Obliterans

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double-Blind, Primary Purpose: Treatment


Minimum age: N/A. Maximum age: N/A. Gender(s): Male.


Inclusion Criteria:

- Documented chemical exposure

- Clinical, spirometric and radiological findings were compatible with BO on High

Resolution Computed Tomography (HRCT)

- Non-responsiveness to high dose bronchodilator therapy

Exclusion Criteria:

- Radiographic evidence of pneumonia, active tuberculosis, lung carcinoma, or an

infection that necessitated the use of an antibiotic

- History of cigarette smoking and occupational exposure to toxic agents of

hypersensitivity to macrolides

- History of treatment with a systemic antibiotic within 7 days before the start of the


- Any investigational medicine within 4 weeks of the study

- History of antibiotic injection within 6 weeks before the study

- Concomitant Theophylline or Carbamazepine, unless their serum concentrations were

regularly monitored

- Patients who were in the exacerbation phase of their respiratory complications

- Need to use medications interact with macrolides such as Digoxin, Theophylline and


- Systemic antibiotics

- Systemic Corticosteroids

- Admission to the hospital

- Abnormal kidney or liver function

Locations and Contacts

Baqiyatallah Medical Sciences University, Tehran 19945-546, Iran, Islamic Republic of
Additional Information

Last updated: November 4, 2008

Page last updated: August 23, 2015

-- advertisement -- The American Red Cross
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017