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Topiramate and Cerebrovascular Response in Migraineurs

Information source: SMG-SNU Boramae Medical Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Migraine Disorders

Intervention: Topiramate (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: SMG-SNU Boramae Medical Center

Official(s) and/or principal investigator(s):
Hyunwoo Nam, MD, PhD, Principal Investigator, Affiliation: SMG-SNU Boramae Medical Center


The purpose of this study is to evaluate the effect of topiramate on cerebrovascular reactivity and mean flow velocity to photic stimulation in migraineurs.

Clinical Details

Official title: Effect of Topiramate on Cerebrovascular Response to Photic Stimulation in Migraineurs

Study design: Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Comparison of the Cerebrovascular reactivity

Secondary outcome: Comparison of the mean flow velocities in the middle and posterior cerebral artery


Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.


Inclusion Criteria:

- aged 18 to 65 years

- newly-diagnosed patients with migraine without aura (International Headache Society


- symptom frequency (at least 2 episodes of migraine attack/month)

Exclusion Criteria:

- prior use of preventive medication

- patients with cardiovascular risk factors (hypertension, diabetes, hyperlipidemia,


- patients who take antihypertensive agent or antidepressant

- patients who were pregnant, breast-feeding or actively smoking

- patients with neurological or cerebrovascular diseases

Locations and Contacts

Additional Information

Starting date: December 2008
Last updated: April 18, 2015

Page last updated: August 23, 2015

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