The Mechanisms of Diameter Changes in Retinal Vessels During Hypoxia
Information source: University of Aarhus
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Retinal Hypoxia
Intervention: COX-inhibitor (Drug); Nitroglycerin (Drug); COX-inhibitor + Nitroglycerin (Drug)
Phase: N/A
Status: Completed
Sponsored by: University of Aarhus Official(s) and/or principal investigator(s): Line Pedersen, MD, Principal Investigator, Affiliation: Aarhus University Hospital Musa Kaya, stud.med, Principal Investigator, Affiliation: Aarhus University Hospital
Summary
The primary objective is to study if a stimulation of nitric oxide and/or prostaglandin
affect the diameter changes of retinal vessels during hypoxia. Diameter changes are studied
using the Dynamic Vessel Analyzer.
Clinical Details
Official title: The Underlying Mechanisms of Diameter Changes in Retinal Vessels During Hypoxia
Study design: Allocation: Non-Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science
Primary outcome: Diameter changes of retinal vessels
Eligibility
Minimum age: 20 Years.
Maximum age: 60 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Age between >19 and <61 years
- No known systemic or ocular diseases
Exclusion Criteria:
- Cardio-vascular disease
- Lung disease
- Epilepsy
- Previous ocular disease
- Previous treatment with medications influencing the intraocular pressure or the
metabolism of nitric oxide or prostaglandins
- Daily intake of medicine except contraceptive pills
- Pregnancy or breastfeeding
- Known allergy against any of the drugs used in the interventions
Locations and Contacts
Department of Ophtalmology, Aarhus University Hospital, Aarhus 8000, Denmark
Additional Information
Starting date: February 2014
Last updated: August 17, 2015
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