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The Mechanisms of Diameter Changes in Retinal Vessels During Hypoxia

Information source: University of Aarhus
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Retinal Hypoxia

Intervention: COX-inhibitor (Drug); Nitroglycerin (Drug); COX-inhibitor + Nitroglycerin (Drug)

Phase: N/A

Status: Completed

Sponsored by: University of Aarhus

Official(s) and/or principal investigator(s):
Line Pedersen, MD, Principal Investigator, Affiliation: Aarhus University Hospital
Musa Kaya, stud.med, Principal Investigator, Affiliation: Aarhus University Hospital


The primary objective is to study if a stimulation of nitric oxide and/or prostaglandin affect the diameter changes of retinal vessels during hypoxia. Diameter changes are studied using the Dynamic Vessel Analyzer.

Clinical Details

Official title: The Underlying Mechanisms of Diameter Changes in Retinal Vessels During Hypoxia

Study design: Allocation: Non-Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science

Primary outcome: Diameter changes of retinal vessels


Minimum age: 20 Years. Maximum age: 60 Years. Gender(s): Both.


Inclusion Criteria:

- Age between >19 and <61 years

- No known systemic or ocular diseases

Exclusion Criteria:

- Cardio-vascular disease

- Lung disease

- Epilepsy

- Previous ocular disease

- Previous treatment with medications influencing the intraocular pressure or the

metabolism of nitric oxide or prostaglandins

- Daily intake of medicine except contraceptive pills

- Pregnancy or breastfeeding

- Known allergy against any of the drugs used in the interventions

Locations and Contacts

Department of Ophtalmology, Aarhus University Hospital, Aarhus 8000, Denmark
Additional Information

Starting date: February 2014
Last updated: August 17, 2015

Page last updated: August 23, 2015

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