Comparison of Low-volume PEG Plus Ascorbic Acid Versus Standard PEG Solution as Bowel Cleansing for Colonoscopy
Information source: Kangbuk Samsung Hospital
ClinicalTrials.gov processed this data on August 20, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Colonoscopy [E01.370.372.250.250.200]
Intervention: polyethylene glycol, ascorbic acid (Drug)
Phase: N/A
Status: Enrolling by invitation
Sponsored by: Dong Il Park, M.D, Ph.D. Official(s) and/or principal investigator(s): Dong Il Park, professor, Principal Investigator, Affiliation: Kangbuk Samsung Hospital
Summary
The purpose of this study is to compare two regimens of low volume (2L) polyethylene
glycol(PEG)plus ascorbic acid versus standard volume (4L) PEG alone for bowel preparation in
out-patients
Clinical Details
Official title: Randomized Controlled Trial of Low-volume PEG Plus Ascorbic Acid Versus Standard PEG Solution as Bowel Cleansing for Colonoscopy
Study design: Observational Model: Case Control, Time Perspective: Prospective
Primary outcome: The efficacy of bowel preparation
Secondary outcome: Patient's compliance and acceptability
Detailed description:
Inadequate bowel preparation may lead to a longer colonoscopy, and to an inability to
identify lesions. PEG can provide a rapid orthograde peroral approach to colonic lavage
without producing significant fluid or electrolyte changes. Thus PEG is now commonly used
for bowel preparation. However, large amounts and unsatisfactory taste of PEG solution are
generally poorly tolerated. a new low volume PEG-based bowel cleansing agents became
available at foreign countries. Although several studies reported the efficacy and improved
compliance of these low volume PEG plus ascorbic acid solution for colonoscopy, but result
in Korean patients was not-recognized.
Eligibility
Minimum age: 19 Years.
Maximum age: 80 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Out-patients for colonoscopy
Exclusion Criteria:
- age under 19 years or over 80 years
- Intestinal obstruction
- Women of pregnant, breastfeeding, or at risk of becoming pregnant
- major psychiatric illness
- known allergy to PEG
- serious condition- severe cardiac, renal, or metabolic diseases
- past history of colon resection
- current acute exacerbation of chronic inflammatory bowel disease
- functional constipation defined by Rome III diagnostic criteria
Locations and Contacts
Kangbuk Samsung Hospital, Seoul 110-746, Korea, Republic of
Additional Information
Starting date: March 2012
Last updated: November 30, 2012
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