The purpose of this study is to find out if combining everolimus with letrozole is safe and
has beneficial effects in postmenopausal women who have estrogen positive HER2 negative
locally advanced or metastatic breast cancer. Additionally, this study aims to find out if
everolimus plus exemestane is safe and has beneficial effects in women with estrogen
positive locally advanced or metastatic breast cancer after treatment with everolimus plus
letrozole. This study will also aim to find out if a mouth rinse can help reduce the
severity of oral stomatitis, a common side effect of everolimus. This part of the study will
be conducted only in countries where an alcohol free 0. 5mg/5ml dexamethasone oral solution
is commercially available.
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Female.
Novartis Investigative Site, Besançon cedex 25030, France
Novartis Investigative Site, Bordeaux 33076, France
Novartis Investigative Site, Hyères 83400, France
Novartis Investigative Site, Le Chesnay 78157, France
Novartis Investigative Site, Lyon Cedex 69373, France
Novartis Investigative Site, Nancy 54000, France
Novartis Investigative Site, Nantes cedex 2 44202, France
Novartis Investigative Site, Gyula 5700, Hungary
Novartis Investigative Site, Kaposvar 7400, Hungary
Novartis Investigative Site, Kecskemet 6000, Hungary
Novartis Investigative Site, Kistarcsa 2143, Hungary
Novartis Investigative Site, Szekszard 7100, Hungary
Novartis Investigative Site, Seoul 135-720, Korea, Republic of
Novartis Investigative Site, Seoul 139-706, Korea, Republic of
Novartis Investigative Site, Maastricht 5800, Netherlands
Novartis Investigative Site, Lisboa 1400-038, Portugal
Novartis Investigative Site, Lisboa 1649-035, Portugal
Novartis Investigative Site, Porto 4200-072, Portugal
Novartis Investigative Site, Bangkok 10330, Thailand
Novartis Investigative Site, Bangkok 10400, Thailand
Novartis Investigative Site, Bangkok 10700, Thailand
Novartis Investigative Site, Altunizade 34662, Turkey
Novartis Investigative Site, Antalya 07059, Turkey
Novartis Investigative Site, Istanbul 34303, Turkey
Novartis Investigative Site, Izmir 35040, Turkey
Novartis Investigative Site, Bath BA1 3NG, United Kingdom
Novartis Investigative Site, Nagoya-city, Aichi 467-8602, Japan
University of Alabama Comprehensive Cancer Center SC-2, Birmingham, Alabama 35294, United States
Banner MD Anderson Cancer Center, Gilbert, Arizona 85234, United States
Novartis Investigative Site, Caba, Buenos Aires C1181ACH, Argentina
Loma Linda University Loma Linda, Loma Linda, California 92354, United States
Breastlink Medical Group Dept. of BreastlinkResearchGrp, Long Beach, California 90806, United States
Novartis Investigative Site, Salamanca, Castilla y Leon 37007, Spain
Novartis Investigative Site, Valencia, Comunidad Valenciana 46010, Spain
Novartis Investigative Site, La Coruna, Galicia 15006, Spain
Novartis Investigative Site, Sapporo, Hokkaido, Japan
Oncology Specialists, SC Dept.of Oncology Specialists, Park Ridge, Illinois 60068-0736, United States
Novartis Investigative Site, Morioka-city, Iwate 020-8505, Japan
Novartis Investigative Site, Kawasaki-city, Kanagawa 216-8511, Japan
St. Francis Health Comprehensive Cancer Center, Topeka, Kansas 66606-169, United States
Norton Healthcare, Inc. SC, Louisville, Kentucky 40202, United States
Novartis Investigative Site, Seoul, Korea 135-710, Korea, Republic of
Novartis Investigative Site, Kumamoto City, Kumamoto 860-8556, Japan
Novartis Investigative Site, Santa Rosa, La Pampa 6300, Argentina
Holy Cross Hospital Holy Cross, Silver Spring, Maryland 20910, United States
Baystate Medical Center SC, Springfield, Massachusetts 00119, United States
Novartis Investigative Site, Posadas, Misiones 3300, Argentina
Mercy Medical Research Institute SC, Manchester, Missouri 63021, United States
Saint Barnabas Medical Center CancerCenter of Saint Barnabas, Livingston, New Jersey 07039, United States
University of New Mexico Hospital SC, Albuquerque, New Mexico 87106, United States
Broome Oncology SC, Johnson City, New York 13790, United States
Columbia University Medical Center- New York Presbyterian Columbia, New York, New York 10032, United States
Cone Health Cancer Center, Greensboro, North Carolina, United States
Marion L. Shepard Cancer Center SC, Washington, North Carolina 27889, United States
Novartis Investigative Site, Porto Alegre, RS 90035-903, Brazil
Novartis Investigative Site, São Paulo, SP 01317-904, Brazil
Novartis Investigative Site, São Paulo, SP 03102-002, Brazil
Novartis Investigative Site, Rosario, Santa Fe S2000KZE, Argentina
East Texas Hematology Clinic SC, Lufkin, Texas 75904, United States
Utah Cancer Specialists Dept.of Utah Cancer Spec. (3), Salt Lake City, Utah 84106, United States