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Severe Pregnancy Complications Are Associated With Elevated Factor VIII Plasma Activity

Information source: Tel-Aviv Sourasky Medical Center
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Pregnancy Complications; Preeclampsia; Placental Abruption; Intrauterine Fetal Growth Restriction; Intrauterine Fetal Death

Phase: N/A

Status: Active, not recruiting

Sponsored by: Tel-Aviv Sourasky Medical Center

Official(s) and/or principal investigator(s):
Eli Rimon, MD, Principal Investigator, Affiliation: Tel Aviv medical center,Israel

Summary

Congenital and acquired thrombophilia were identified as risk factors for thrombosis in systemic vessels. Thrombophilias have also been recently found to be associated with preeclampsia, intrauterine fetal growth restriction (IUGR), placental abruption, intrauterine fetal death (IUFD) and repeated pregnancy loss. These severe pregnancy complications are thought to result from thrombotic events occurring in the uteroplacental circulation. Accumulating data have established an association between elevated plasma activity of factor VIII and thrombosis although the mechanism is still not defined and elevated factor VIII activity is now regarded as being equivalent to thrombophilia. We intend to investigatthe association between factor VIII levels and severe pregnancy complications which are considered to result from placental vascular pathology, i. e., preeclampsia, IUGR, placental abruption and IUFD. We hypothezise that the prevalence of elevated factor 8 will be higher among women with pregnancy complications compared to controls.

Clinical Details

Official title: A Retrospective Analysis of Possible Association Between Severe Pregnancy Complications and Elevated Factor VIII Plasma Activity.

Study design: Observational Model: Case Control, Time Perspective: Retrospective

Primary outcome: prevalenc of elevated factor VIII

Eligibility

Minimum age: 18 Years. Maximum age: 45 Years. Gender(s): Female.

Criteria:

Inclusion Criteria:

- Women who had either normal pregnancy or complicated pregnancy.

Exclusion Criteria:

- Other causes of pregnancy complication such as infections, anomalies and fetal

malformations

Locations and Contacts

Tel Avis sourasky medical center, Tel Aviv 64239, Israel
Additional Information

Starting date: January 2000
Last updated: December 12, 2007

Page last updated: August 23, 2015

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