Severe Pregnancy Complications Are Associated With Elevated Factor VIII Plasma Activity
Information source: Tel-Aviv Sourasky Medical Center
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Pregnancy Complications; Preeclampsia; Placental Abruption; Intrauterine Fetal Growth Restriction; Intrauterine Fetal Death
Phase: N/A
Status: Active, not recruiting
Sponsored by: Tel-Aviv Sourasky Medical Center Official(s) and/or principal investigator(s):
Eli Rimon, MD, Principal Investigator, Affiliation: Tel Aviv medical center,Israel
Summary
Congenital and acquired thrombophilia were identified as risk factors for thrombosis in
systemic vessels. Thrombophilias have also been recently found to be associated with
preeclampsia, intrauterine fetal growth restriction (IUGR), placental abruption, intrauterine
fetal death (IUFD) and repeated pregnancy loss. These severe pregnancy complications are
thought to result from thrombotic events occurring in the uteroplacental circulation.
Accumulating data have established an association between elevated plasma activity of factor
VIII and thrombosis although the mechanism is still not defined and elevated factor VIII
activity is now regarded as being equivalent to thrombophilia.
We intend to investigatthe association between factor VIII levels and severe pregnancy
complications which are considered to result from placental vascular pathology, i. e.,
preeclampsia, IUGR, placental abruption and IUFD. We hypothezise that the prevalence of
elevated factor 8 will be higher among women with pregnancy complications compared to
controls.
Clinical Details
Official title: A Retrospective Analysis of Possible Association Between Severe Pregnancy Complications and Elevated Factor VIII Plasma Activity.
Study design: Case Control, Retrospective
Primary outcome: prevalenc of elevated factor VIII
Eligibility
Minimum age: 18 Years.
Maximum age: 45 Years.
Gender(s): Female.
Criteria:
Inclusion Criteria:
- Women who had either normal pregnancy or complicated pregnancy.
Exclusion Criteria:
- Other causes of pregnancy complication such as infections, anomalies and fetal
malformations
Locations and Contacts
Tel Avis sourasky medical center, Tel Aviv 64239, Israel
Additional Information
Starting date: January 2000
Ending date: January 2008
Last updated: December 12, 2007
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