A Randomized Evaluation of the Effect of Routine Normal Saline Flush Versus Heparinized Saline Solution in Groshong and Groshong PICC Catheters
Information source: National Institutes of Health Clinical Center (CC)
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Catheters, Indwelling; Thrombosis
Phase: N/A
Status: Completed
Sponsored by: National Institutes of Health Clinical Center (CC)
Summary
The Groshong and Groshong PICC catheters are popular venous access devices because they are
maintained with only weekly saline flushes. In a recent study, however, we found an apparent
decrease in the rate of withdrawal occlusion in Groshong catheters flushed weekly with
heparinized saline. However, a randomized trial is necessary to confirm this impression. In
the current study as many as 66 patients will be randomized to each of two treatment arms.
The Groshong catheters of one group will be flushed with saline only and the other group with
heparinized saline. A comparison will be made between the frequency with which urokinase is
used in the two groups to treat withdrawal occlusion during the first three months of
catheterization. Groshong catheters using saline flushes will be compared to Groshong
catheters using heparinized saline flushes and Groshong PICC catheters using saline flushes
will be compared to Groshong PICC catheters using heparinized saline flushes. Data will be
analyzed using Fisher's exact test.
Clinical Details
Official title: A Randomized Evaluation of the Effect of Routine Normal Saline Flush Versus Heparinized Saline Solution in Groshong and Groshong PICC Catheters
Study design: N/A
Detailed description:
The Groshong and Groshong PICC catheters are popular venous access devices because they are
maintained with only weekly saline flushes. In a recent study, however, we found an apparent
decrease in the rate of withdrawal occlusion in Groshong catheters flushed weekly with
heparinized saline. However, a randomized trial is necessary to confirm this impression. In
the current study as many as 66 patients will be randomized to each of two treatment arms.
The Groshong catheters of one group will be flushed with saline only and the other group with
heparinized saline. A comparison will be made between the frequency with which urokinase is
used in the two groups to treat withdrawal occlusion during the first three months of
catheterization. Groshong catheters using saline flushes will be compared to Groshong
catheters using heparinized saline flushes and Groshong PICC catheters using saline flushes
will be compared to Groshong PICC catheters using heparinized saline flushes. Data will be
analyzed using Fisher's exact test.
Eligibility
Minimum age: N/A.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Adult subjects enrolled in approved protocols of the NCI in the CC or under treatment at
the National Naval Medical Center who are planned to have Groshong Catheters used as part
of their cancer treatment.
No subjects with a history of allergy to heparin.
No abnormal PT or PTT.
No subjects on anticoagulant therapy.
No history of heparin induced thrombocytopenia.
Locations and Contacts
Warren G. Magnuson Clinical Center (CC), Bethesda, Maryland 20892, United States
Additional Information
Related publications: Mayo DJ, Horne MK 3rd, Summers BL, Pearson DC, Helsabeck CB. The effects of heparin flush on patency of the Groshong catheter: a pilot study. Oncol Nurs Forum. 1996 Oct;23(9):1401-5.
Starting date: January 1996
Ending date: November 2000
Last updated: March 3, 2008
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