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Tomographic Comparison of Aerosol Lung Distribution With Two Nebulizers Through a High Flow Nasal Cannula

Information source: Cliniques universitaires Saint-Luc- Université Catholique de Louvain
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Healthy

Intervention: Technetium-99m - Diethylenetriaminepentaacetic acid (Drug); Aeroneb Solo (Device); Jet Nebulizer (Device); Single photon emission computed tomography (Other); Spirometry (Other)

Phase: N/A

Status: Active, not recruiting

Sponsored by: Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Summary

Vibrating-mesh nebulizers ensure currently the best deposition output and are recommended in routine use in intensive care unit. However, jet nebulizers remain the most frequently used nebulizers. On a bench study, aerosol delivery through a high flow nasal cannula (HFNC) was increased using a vibrating-mesh nebulizer as compared to a jet nebulizer. Lung distribution of nebulized particles delivered through a HFNC has never been investigated in vivo. The aim of this study was to compare aerosol lung distribution with both nebulizers through a HFNC by SPECT-CT.

Clinical Details

Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Investigator, Outcomes Assessor)

Primary outcome: Pulmonary deposition

Secondary outcome: Three-dimensional penetration index

Eligibility

Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Male.

Criteria:

Inclusion Criteria:

- Healthy respiratory function

Exclusion Criteria:

- Pulmonary disease

Locations and Contacts

Cliniques Universitaires Saint-Luc, Brussels 1200, Belgium
Additional Information

Starting date: April 2015
Last updated: April 24, 2015

Page last updated: August 23, 2015

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