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Effect of Real-fire Training on Vascular Function

Information source: University of Edinburgh
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Vascular Function; Atherothrombosis

Intervention: Forearm Vascular Study (Procedure); Badimon Chamber Study (Procedure)

Phase: N/A

Status: Recruiting

Sponsored by: University of Edinburgh

Official(s) and/or principal investigator(s):
David E Newby, MD PhD, Study Chair, Affiliation: University of Edinburgh
Nicholas L Mills, MBChB PhD, Study Director, Affiliation: University of Edinburgh
Amanda L Hunter, MBChB, Principal Investigator, Affiliation: University of Edinburgh

Overall contact:
Amanda L Hunter, MBChB, Phone: +441312426437, Email: amanda.hunter@ed.ac.uk

Summary

Fire-fighters are at increased risk of death from heart attacks when compared to other emergency service professionals whose jobs involve similar components such as emergency call-outs and shift work. The unique risk to fire-fighters is likely to reflect a combination of factors including extreme physical exertion, mental stress, heat and pollutant exposure. In the largest analysis of cause of death amongst on-duty fire-fighters, fire-fighter deaths were classified according to the duty performed during the onset of symptoms or immediately prior to any sudden death. The majority of deaths due to a cardiovascular cause (i. e. heart attack) occurred during fire-suppression whilst this activity represented a relatively small amount of a fire-fighters professional time. Fire simulation training centers offer a unique opportunity to assess the heart, blood and blood vessel response to fire suppression in a controlled environment. In this study the investigators will assess healthy career fire-fighters on two occasions: following a fire-suppression training exercise in a purpose built real-fire training center, and following a sedentary period as a control. The investigators will take blood samples to measure platelet activity (platelets are the particles in blood that help blood clot) and will examine how blood clots outside of the body. The investigators will then perform studies placing small needles in the arm to assess blood vessel function following fire suppression. By undertaking this comprehensive assessment of blood, blood vessel and heart function we hope to understand the mechanisms whereby the risk of a heart attack is influenced by fire suppression. The investigators hypothesize that following the fire-suppression exercise firefighters blood will clot more readily and their blood vessels will not relax properly which are two of the main processes in the development of a heart attack.

Clinical Details

Official title: Effect of Real-fire Training on Vascular Function

Study design: Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Basic Science

Primary outcome: Forearm blood flow measured by venous occlusion plethysmography in response to infused vasodilators

Secondary outcome:

Ex-vivo thrombus formation using the Badimon chamber

Plasma t-PA and PAI concentrations following infusion of bradykinin

Eligibility

Minimum age: 18 Years. Maximum age: 60 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Non-smoking healthy firefighters

Exclusion Criteria:

- Current smoker

- History of lung or ischaemic heart disease

- Malignant arrhythmia

- Systolic blood pressure >190mmHg or <100mmHg

- Renal or hepatic dysfunction

- Previous history of blood dyscrasia

- Unable to tolerate the supine position

- Blood donation within the last 3 months

- Recent respiratory tract infection within the past 4 weeks

- Routine medication including aspirin and NSAIDs

Locations and Contacts

Amanda L Hunter, MBChB, Phone: +441312426437, Email: amanda.hunter@ed.ac.uk

Royal Infirmary of Edinburgh Clinical Research Facility, Edinburgh EH16 4SA, United Kingdom; Recruiting
Amanda L Hunter, MBChB, Phone: +441312426437, Email: amanda.hunter@ed.ac.uk
Nicholas L Mills, MBChB PhD, Phone: +441312426437, Email: nick.mills@ed.ac.uk
Amanda L Hunter, MBChB, Principal Investigator
Additional Information

Starting date: April 2012
Last updated: March 13, 2013

Page last updated: August 23, 2015

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