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The Use of Low Level Laser Therapy for Wound Healing in Leprosy Patients

Information source: Para Federal University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Leprosy

Intervention: Routine treatment (Procedure); Low level laser therapy (LLLT) (Radiation)

Phase: N/A

Status: Completed

Sponsored by: Para Federal University

Official(s) and/or principal investigator(s):
Claudio G Salgado, Dr, Study Director, Affiliation: Federal University of Pará

Summary

Neuropathic ulcers are common sequelae of leprosy. The objectives of this study are to analyze the clinic-epidemiological characteristics of patients attended at one specialized dressing service from a leprosy-endemic region of the Brazilian Amazon and to evaluate the effect of Low Level Laser Therapy on wound healing of these patients.

Clinical Details

Official title: Clinic-Epidemiological Evaluation of Ulcers in Leprosy Patients and the Use of Low Level Laser Therapy: a Randomized Clinical Trial

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Wound healing

Secondary outcome: Ulcer surface area, depth and PUSH tool score.

Eligibility

Minimum age: N/A. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- presented with neuropathic ulcer

- attended at least 3 weekly appointments at the dressing service of UREMC

- completed specific multi-drug therapy for M. leprae

- gave written informed consent to participate in the study

Exclusion Criteria:

- clinically detectable infection in the ulcer

- use of drugs, like corticosteroids that could interfere with the wound healing

process

- use of special dressings like hydrocolloid, calcium alginate, activated carbon or any

kind of therapeutic procedure different from that used routinely for both groups of study

- non-attendance to therapeutic program (six sequential times or nine intercalated)

- pregnancy

- discomfort during treatment procedure

Locations and Contacts

Dr. Marcello Candia Reference Unit in Sanitary Dermatology of the State of Pará in Brazil (UREMC), Marituba, Pará 67200-000, Brazil
Additional Information

Related publications:

Flemming K, Cullum N. Laser therapy for venous leg ulcers. Cochrane Database Syst Rev. 2000;(2):CD001182. Review. Update in: Cochrane Database Syst Rev. 2014;7:CD001182.

Hopkins JT, McLoda TA, Seegmiller JG, David Baxter G. Low-Level Laser Therapy Facilitates Superficial Wound Healing in Humans: A Triple-Blind, Sham-Controlled Study. J Athl Train. 2004 Sep;39(3):223-229.

Schindl A, Schindl M, Pernerstorfer-Schön H, Mossbacher U, Schindl L. Low intensity laser irradiation in the treatment of recalcitrant radiation ulcers in patients with breast cancer--long-term results of 3 cases. Photodermatol Photoimmunol Photomed. 2000 Feb;16(1):34-7.

Lucas C, van Gemert MJ, de Haan RJ. Efficacy of low-level laser therapy in the management of stage III decubitus ulcers: a prospective, observer-blinded multicentre randomised clinical trial. Lasers Med Sci. 2003;18(2):72-7.

Franek A, Król P, Kucharzewski M. Does low output laser stimulation enhance the healing of crural ulceration? Some critical remarks. Med Eng Phys. 2002 Nov;24(9):607-15.

Schubert V. Effects of phototherapy on pressure ulcer healing in elderly patients after a falling trauma. A prospective, randomized, controlled study. Photodermatol Photoimmunol Photomed. 2001 Feb;17(1):32-8.

Pereira AN, Eduardo Cde P, Matson E, Marques MM. Effect of low-power laser irradiation on cell growth and procollagen synthesis of cultured fibroblasts. Lasers Surg Med. 2002;31(4):263-7.

Starting date: November 2006
Last updated: December 12, 2009

Page last updated: August 23, 2015

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