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Effect of Sufentanil on the Rate of Anesthesia

Information source: Islamic Azad University, Tehran
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Irreversible Pulpitis

Intervention: Lidocaine with Epinephrine+ Normal saline (Drug); Lidocaine with Epinephrine + sufentanil (Drug)

Phase: Phase 2

Status: Completed

Sponsored by: Islamic Azad University, Tehran

Official(s) and/or principal investigator(s):
Mandana Abedi Tari, Dentist, Principal Investigator, Affiliation: Dental School of Azad University


The aim of this study was to compare the effects of Lidocaine/epinephrine with and without Sufentanil on the rate of anesthesia after supplemental intraligamentary injection (PDL) in teeth with irreversible pulpitis.

Clinical Details

Official title: Comparison the Effect of Lidocaine (With Epinephrine) With and Without Sufentanil on the Rate of Anesthesia of Intra-ligamentary Injection in Teeth With Irreversible Pulpitis

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention

Primary outcome: depth of anesthesia

Secondary outcome: intensity of the pain


Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.


Inclusion Criteria:

- patients in the age group of 18-65 years old

- healthy (ASA I, II)

- patients with first or second mandibular molars who need endodontic treatment

- vital tooth without a history of past endodontic treatment

- patients with clinical evidence of irreversible Pulpits with moderate to severe pain

- patients who signed consent form

- patients numbness at the lateral edge of the lips after inferior alveolar injection

(INA) and those with positive respond to maximum output of pulp tester after INA. Exclusion Criteria:

- pregnant or nursing

- necrotic tooth

- patients with allergy or contraindication toward non-opioid or opioid painkillers

such as aspirin or NSAIDs

- Patients who have taken opioid or non opioid or steroid pain killers, antidepressants

or sedative drugs in the past 48 hours

- patient with infectious diseases

- patient with moderate to sever periodontal disease

- those without numbness at the lateral edge of the lips after inferior alveolar

injection (INA), and those do not respond to maximum output of pulp tester after INA.

Locations and Contacts

Dental School of Azad University, Tehran, Iran, Islamic Republic of
Additional Information

Starting date: January 2010
Last updated: April 4, 2012

Page last updated: August 23, 2015

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