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Evaluation of Neuroprotective Effect of Minocycline

Information source: Shahid Beheshti Medical University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Retinal Detachment

Intervention: placebo (Drug); Minocycline (Drug)

Phase: Phase 2

Status: Recruiting

Sponsored by: Shahid Beheshti Medical University

Summary

This process appears as a incredible and progressive event that will not stop till reattachment of RPE and neurosensory retina happened . Process of degeneration begins from first hours of RD (Retinal Detachment) establishment Neuroprotection of photoreceptor following RD is a novel and debatable discussion encountered in recent years . How to stop this phenomena and neuroprotective agent role in this issue are a new interest of researcher. In the study the investigators are planning to perform a clinical trial to demonstrate the minocycline neuroprotective effect in a double blind design as this impact has been implicated previously in a animal study

Clinical Details

Official title: Evaluation of Minocycline Neuro Protective Role in Retinal Detachment Surgery

Study design: Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention

Primary outcome: BCVA

Secondary outcome:

finding of ERG changes

finding of OCT changes

finding of FAF changes

Eligibility

Minimum age: 8 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- age over 8 years old

- gender of both sex

- normal liver and renal function

- informed consent received from all patients

- no pregnancy and no lactation

- minimal sun exposure

Exclusion Criteria:

- old RD

- diabetic retina

- previous retinal surgery CRF& liver disfunction RD + PVR > B Hyper sensitivity to

tetracycline History previous MPC or PRP Patients unsuccessful SB (retina is off )

Locations and Contacts

Labbafinejad medical center, Tehran, Iran, Islamic Republic of; Recruiting
Mohsen Azarmina, Associate Professor, Phone: 00982122585952, Email: labbafi@hotmail.com
Mohsen Azarmina, Associate Professor, Principal Investigator
Additional Information

Starting date: December 2010
Last updated: February 16, 2011

Page last updated: August 23, 2015

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