Evaluation of Neuroprotective Effect of Minocycline
Information source: Shahid Beheshti Medical University
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Retinal Detachment
Intervention: placebo (Drug); Minocycline (Drug)
Phase: Phase 2
Status: Recruiting
Sponsored by: Shahid Beheshti Medical University
Summary
This process appears as a incredible and progressive event that will not stop till
reattachment of RPE and neurosensory retina happened .
Process of degeneration begins from first hours of RD (Retinal Detachment) establishment
Neuroprotection of photoreceptor following RD is a novel and debatable discussion
encountered in recent years .
How to stop this phenomena and neuroprotective agent role in this issue are a new interest
of researcher.
In the study the investigators are planning to perform a clinical trial to demonstrate the
minocycline neuroprotective effect in a double blind design as this impact has been
implicated previously in a animal study
Clinical Details
Official title: Evaluation of Minocycline Neuro Protective Role in Retinal Detachment Surgery
Study design: Allocation: Randomized, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Prevention
Primary outcome: BCVA
Secondary outcome: finding of ERG changesfinding of OCT changes finding of FAF changes
Eligibility
Minimum age: 8 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- age over 8 years old
- gender of both sex
- normal liver and renal function
- informed consent received from all patients
- no pregnancy and no lactation
- minimal sun exposure
Exclusion Criteria:
- old RD
- diabetic retina
- previous retinal surgery CRF& liver disfunction RD + PVR > B Hyper sensitivity to
tetracycline History previous MPC or PRP Patients unsuccessful SB (retina is off )
Locations and Contacts
Labbafinejad medical center, Tehran, Iran, Islamic Republic of; Recruiting Mohsen Azarmina, Associate Professor, Phone: 00982122585952, Email: labbafi@hotmail.com Mohsen Azarmina, Associate Professor, Principal Investigator
Additional Information
Starting date: December 2010
Last updated: February 16, 2011
|