The Efficacy of Nitric Oxide in Stroke (ENOS) Trial

Condition(s) targeted: Stroke

Intervention: Transdermal glyceryl trinitrate patch (Drug); Pre-stroke antihypertensives (Drug)

Phase: Phase 3

Status: Recruiting

Sponsored by: University of Nottingham

Official(s) and/or principal investigator(s):
Philip Bath, Principal Investigator, Affiliation: University of Nottingham

Overall contact:
Philip Bath, Email: philip.bath@nottingham.ac.uk

Nitric oxide is a multimodal candidate treatment for acute stroke having a number of properties which may be beneficial in acute stroke, including lowering blood pressure, causing cerebral vasodilation, and improving central and systemic haemodynamics. Nitric oxide donors are effective in experimental stroke and pilot studies in patients suggest that one, glyceryl trinitrate, can be delivered easily in a transdermal preparation. Around half of all patients admitted with acute stroke are taking antihypertensive therapy immediately prior to their stroke. No data exist as to whether it is beneficial or safe to stop or continue this treatment during the acute phase. ENOS is a prospective, international, multicentre, randomised, parallel-group, blinded, controlled, collaborative, factorial trial designed to test two questions related to the management of blood pressure immediately post-stroke: 1. The safety and efficacy of nitric oxide, given as transdermal glyceryl trinitrate. 2. The safety and efficacy of stopping or continuing prior antihypertensive medication. Previously independent adult patients who are conscious and have residual limb weakness are eligible for enrollment. Central randomisation will be performed via the internet. Treatment is initiated within 48 hours of stroke onset and is given as daily glyceryl trinitrate patches for 7 days. A computed tomography (CT) scan is required within 7 days of randomisation. Early follow-up is performed locally over the 7 days of treatment, including blood pressure, early stroke events, and adverse events. Telephone central follow-up by the trial co-ordinating centre will be performed at 3 months. The primary outcome is combined death or dependency (modified Rankin Score >2).

Official title: A Prospective, Collaborative, International, Multicentre, Randomised, Parallel-group, Single and Outcome Blinded, Controlled, Factorial Trial to Investigate the Safety and Efficacy of Treatment With Transdermal Glyceryl Trinitrate, a Nitric Oxide Donor, and of Continuing or Stopping Temporarily Pre-stroke Antihypertensive Therapy, in Patients With Acute Stroke

Study design: Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment

Primary outcome: Reduced death or dependency (modified Rankin score)

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Adult(> 18 yrs).

- Clinical stroke syndrome with limb weakness lasting at least 1 hour i. e. not likely

to be a transient ischaemic attack).

- Limb weakness (SNSS Arm <6 and/or Leg <6).

- Onset < 48 hours.

- Conscious (Glasgow Coma Scale > 8).

- Independent prior to stroke (pre-morbid Rankin scale < 2).

- Meaningful consent, or assent from a relative or carer

Exclusion Criteria:

- Definite need for nitrate therapy

- Contraindication to nitrate therapy

- Definite need for prior antihypertensive or anti-anginal medication

- Definite need for antihypertensive therapy during acute stroke

- Systolic blood pressure <140 mmHg or >220 mmHg.

- Patients expected to require surgical intervention

- Known intracerebral pathology other than stroke

- Other serious condition which is likely to prevent outcome assessment at 3 months

- Previous enrollment in ENOS or current involvement in another trial of an

experimental drug intervention.

- Not available for follow-up -Females of childbearing potential, pregnancy or

breastfeeding. -

Philip Bath, Email: philip.bath@nottingham.ac.uk

Nottingham University Hospitals NHS Trust (City Hospital), Nottingham, Nottinghamshire NG5 1PJ, United Kingdom; Recruiting

Starting date: July 2001
Last updated: July 23, 2012