Insulin Sensitivity and Metabolism Before and After Treatment in Patients With Hypothyroidism

Condition(s) targeted: Hypothyroidism

Intervention: Levothyroxin (Drug)

Phase: N/A

Status: Not yet recruiting

Sponsored by: University of Aarhus

Overall contact:
Jens OL Jorgensen, Phone: 0045 8949 2025, Email: joj@ki.au.dk

The aim of this study is to further characterize the treatment related changes in insulin sensitivity, substrate metabolism and intra hepatic- and intramyocellular lipid content in patients with hypothyroidism

Official title: Insulin Sensitivity and Metabolism Before and After Treatment in Patients With Hypothyroidism

Study design: Basic Science, Open Label, Uncontrolled, Single Group Assignment

Primary outcome:

intracellular lipid content in liver and muscle

intraabdominal lipid content

insulin sensitivity

substrate metabolism

intracellular signaling in the basal state and during insulin stimulation

Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- written informed consent

- must be of legal age and competent

- Age > 18 years

- presently diagnosed with hypothyroidism

Exclusion Criteria:

- alcohol consumption >21 units per week

- Malignant disease

- pregnancy

- magnetic implants or material in the body

- BMI > 30

- Heart disease (NYHA >2)

- Uncontrolled hypertension

- Manifest diabetes mellitus

- Changes in medication, with any influence on glucose metabolism, 2 months prior to

and until the end of the trial.

Jens OL Jorgensen, Phone: 0045 8949 2025, Email: joj@ki.au.dk

Medical department M (Endocrinology and Diabetes), Aarhus University Hospital, Aarhus Sygehus,, Aarhus 8000, Denmark

(Central Denmark Region Committee on Biomedical Research Ethics)

(Jens Otto Lunde Jorgensen)

Louise Møller

(Danish Data Protection Agency)

Starting date: January 2009
Ending date: January 2010
Last updated: July 24, 2009