Efficacy of Preoperative Intravenous Dexamethasone in Primary Total Knee Arthroplasty
Information source: Thammasat University
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Postoperative Pain
Intervention: Dexamethasone (Drug); Normal saline (Drug)
Phase: Phase 4
Status: Recruiting
Sponsored by: Thammasat University Official(s) and/or principal investigator(s): Supakit Kanitnate, M.D., Principal Investigator, Affiliation: Orthopaedics department, Thammasat University
Overall contact: Supakit Kanitnate, M.D., Phone: 6629269775, Email: naypeng@hotmail.com
Summary
To determine efficacy of preoperative IV dexamethasone for postoperative pain control after
TKA.
Clinical Details
Official title: Efficacy of Preoperative Intravenous Dexamethasone in Controlling Postoperative Pain After Primary Total Knee Arthroplasty: A Randomized Double-blinded Controlled Trial
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Primary outcome: post-operative pain
Secondary outcome: Functional knee scorepost-operative nausea and vomiting complication of preoperative dexamethasone
Detailed description:
Preoperative intravenous over 0. 1 mg/kg of dexamethasone could be reduced pain after primary
TKA.
Eligibility
Minimum age: 50 Years.
Maximum age: 85 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Osteoarthritis of the knee who undergoing unilateral primary total knee arthroplasty
- 50-85 years old
- ASA class 1-3
Exclusion Criteria:
- Unable to perform spinal anaesthesia
- History of drug allergies: steroids
- Renal impairment (CrCl <30 mL/min)
- Liver impairment
- Cognitive function disorders
- Poor controlled DM (HA1C > 7. 5)
- Morning DTX at operative day > 180 mg%
- Received corticosteroids within 3 months before surgery
Locations and Contacts
Supakit Kanitnate, M.D., Phone: 6629269775, Email: naypeng@hotmail.com
Orthopaedic department, Faculty of medicine, Thammasat university, Klongluang, Pathumthani 066, Thailand; Recruiting supakit kanitnate, Phone: 6629269775, Email: naypeng@hotmail.com
Additional Information
Starting date: March 2014
Last updated: April 4, 2014
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