Effect of Desmopressin on Platelet Function in CKD Patients on Antiplatelet Drug
Information source: University of Ulsan
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Bleeding; Tachycardia; Dyspnea
Intervention: Desmopressin administration (Drug)
Phase: Phase 1
Status: Completed
Sponsored by: University of Ulsan
Summary
Prolonged Collagen/Epinephrine - closure time (CEPI-CT) indicates platelet dysfunction in
CKD patients taking antiplatelet agent. The synthetic vasopressin derivative, Desmopressin
(DDAVP) shortens the prolonged bleeding time and improves platelet dysfunction measured by
in vitro closure time: CEPI-CT in uremic patients. Desmopressin also antagonizes the in
vitro platelet dysfunction induced by GPIIb/IIIa inhibitors, clopidogrel and aspirin. The
investigators designed a prospective study to evaluate the effect of desmopressin on
platelet function, as measured by in vitro collagen/epinephrine - closure time, in uremic
patients who were taking antiplatelet drugs.
Clinical Details
Official title: Effect of Desmopressin on Platelet Function in CKD Patients on Antiplatelet Agent Who Need Emergent Temporary Catheter Insertion for Hemodialysis
Study design: Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Primary outcome: collagen-epinephrine closure time
Secondary outcome: Bleeding after procedure
Eligibility
Minimum age: 20 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- adult uremic patients with one or more antiplatelet medication,
- prolonged collagen/epinephrine (CEPI) closure time,
- need for emergent hemodialysis and
- subsequent catheter insertion
Exclusion Criteria:
- acute coronary syndrome,
- hemophilia, and nephrogenic diabetes insipidus,
- allergy against desmopressin
Locations and Contacts
Asan Medical Center, Seoul, Songpa-gu 138-736, Korea, Republic of
Additional Information
Starting date: August 2012
Last updated: May 9, 2013
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