DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more



Effect of Desmopressin on Platelet Function in CKD Patients on Antiplatelet Drug

Information source: University of Ulsan
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Bleeding; Tachycardia; Dyspnea

Intervention: Desmopressin administration (Drug)

Phase: Phase 1

Status: Completed

Sponsored by: University of Ulsan

Summary

Prolonged Collagen/Epinephrine - closure time (CEPI-CT) indicates platelet dysfunction in

CKD patients taking antiplatelet agent. The synthetic vasopressin derivative, Desmopressin (DDAVP) shortens the prolonged bleeding time and improves platelet dysfunction measured by in vitro closure time: CEPI-CT in uremic patients. Desmopressin also antagonizes the in vitro platelet dysfunction induced by GPIIb/IIIa inhibitors, clopidogrel and aspirin. The investigators designed a prospective study to evaluate the effect of desmopressin on

platelet function, as measured by in vitro collagen/epinephrine - closure time, in uremic

patients who were taking antiplatelet drugs.

Clinical Details

Official title: Effect of Desmopressin on Platelet Function in CKD Patients on Antiplatelet Agent Who Need Emergent Temporary Catheter Insertion for Hemodialysis

Study design: Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: collagen-epinephrine closure time

Secondary outcome: Bleeding after procedure

Eligibility

Minimum age: 20 Years. Maximum age: N/A. Gender(s): Both.

Criteria:

Inclusion Criteria:

- adult uremic patients with one or more antiplatelet medication,

- prolonged collagen/epinephrine (CEPI) closure time,

- need for emergent hemodialysis and

- subsequent catheter insertion

Exclusion Criteria:

- acute coronary syndrome,

- hemophilia, and nephrogenic diabetes insipidus,

- allergy against desmopressin

Locations and Contacts

Asan Medical Center, Seoul, Songpa-gu 138-736, Korea, Republic of
Additional Information

Starting date: August 2012
Last updated: May 9, 2013

Page last updated: August 23, 2015

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017