Interaction Between Antihypertensives and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Information source: University of Split
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Hypertension
Intervention: acetaminophen (Drug); ibuprofen (Drug); piroxicam (Drug)
Phase: Phase 4
Status: Completed
Sponsored by: University of Split Official(s) and/or principal investigator(s):
Zvonko - Rumboldt, MD, PhD, Study Director, Affiliation: Split University School of Medicine
Summary
NSAIDs may increase blood pressure and blunt the effects of many antihypertensives. Members
of these drug classes differ in their propensity to such an interaction.
Clinical Details
Official title: Relevance of the Interaction Between Antihypertensive and Antirheumatic Drugs in a Family Practice
Study design: Treatment, Randomized, Single Blind (Outcomes Assessor), Active Control, Factorial Assignment, Efficacy Study
Primary outcome: Arterial blood pressure
Secondary outcome: Body weight,serum electrolytes, urinary electrolytes (Na, K)
Detailed description:
To compare prospectively the effects of piroxicam, ibuprofen and acetaminophen on blood
pressure control in hypertensive patients with osteoarthritis.
Eligibility
Minimum age: 55 Years.
Maximum age: 78 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Treated hypertensives of either gender aged between 55 and 76 years
- About 50% with concomitant osteoarthritis of the hip or knee
Exclusion Criteria:
- Normotensive persons or untreated hypertensives
- Individuals outside the age limits
- General exclusion criteria (e. g. uncooperative persons, advanced malignancies,
participants in other studies)
Locations and Contacts
Split University School of Medicine. Family Practice Department, Split 21000, Croatia
Additional Information
Split University School of Medicine
Related publications: Pavlicević I, Rumboldt M, Rumboldt Z. [Untoward interactions between antihypertensives and nonsteroidal anti-inflammatory drugs] Lijec Vjesn. 2005 Jul-Aug;127(7-8):168-72. Review. Croatian.
Starting date: January 2005
Ending date: September 2006
Last updated: March 7, 2008
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