Metabolic Effects of Subchronic Dopamine D2 Receptor Blockade by Haloperidol in Healthy Humans
Information source: Leiden University Medical Center
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Insulin Resistance; Dyslipidemia
Intervention: Haloperidol (Drug)
Phase: N/A
Status: Completed
Sponsored by: Leiden University Medical Center
Summary
We hypothesized that short-term treatment with haloperidol induces insulin resistance through
a mechanistic route that is independent of weight gain. We therefore treated healthy
non-obese men with haloperidol for 8 days, and studied the impact of these intervention on
glucose and lipid metabolism by hyperinsulinemic euglycemic clamp, isotope dilution
technology and indirect calorimetry.
Clinical Details
Official title: Metabolic Effects of Subchronic Dopamine D2 Receptor Blockade by Haloperidol in Healthy Humans
Study design: Other, Open Label, Single Group Assignment
Primary outcome: To determine the effect of subchronic haloperidol treatment on HGO, whole body peripheral glucose disposal, fatty acid flux and fuel oxidation.
Eligibility
Minimum age: 20 Years.
Maximum age: 40 Years.
Gender(s): Male.
Criteria:
Inclusion Criteria:
- Healthy men
- 20 kg/m2 < BMI < 26 kg/m2
- Age 20-40 years
- FPG < 6 mmol/L
Exclusion Criteria:
- FPG > 6 mmol/L
- BMI > 26 kg/m2
- Psychiatric disorders and/or use of antipsychotic or antidepressants drugs at present
or in the past.
- A positive family history of schizophrenia
- Any significant chronic disease
- Renal, hepatic or endocrine disease
- Use of medication known to influence lipolysis and/or glucose metabolism
- Total cholesterol > 7mmol/L and/or triglycerides > 2 mmol/L
- Recent weight changes or attempts to loose weight (> 3 kg weight gain or loss, within
the last 3 months)
- Difficulties to insert an intravenous catheter
- Smoking (current)
- Severe claustrophobia (ventilated hood)
- Recent blood donation (within the last 2 months)
- Recent participation in other research projects (within the last 3 months),
participation in 2 or more projects in one year
- Extensive sporting activities (more than 10 hours of exercise per week)
Locations and Contacts
Leiden University Medical Center, Leiden 2300 RC, Netherlands
Additional Information
Starting date: March 2005
Ending date: July 2005
Last updated: February 19, 2008
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