Piperacillin as a Part of Antibiotic Streamlining in the Intensive Care Unit
Information source: University of Pittsburgh
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Gram-negative Bacterial Infections
Phase: N/A
Status: Active, not recruiting
Sponsored by: University of Pittsburgh Official(s) and/or principal investigator(s):
David Paterson, MD, Principal Investigator, Affiliation: University of Pittsburgh
Summary
The proposed endpoints of the study would be: comparative use of piperacillin versus broader
spectrum agents (e. g., piperacillin/tazobactam, etc.) [measured as defined daily doses per
1000 patient days]; physician acceptance of piperacillin as part of a streamlining program
[measured as successful occurrences of the use of piperacillin as streamlining therapy];
changes in susceptibility patterns of broad spectrum antibiotics [measured as % Gram
negative bacilli susceptible to each of the commonly used broad spectrum antibiotics]; and
outcome of patients treated with streamlined therapy.
Clinical Details
Official title: Piperacillin as a Part of Antibiotic Streamlining in the Intensive Care Unit
Study design: Time Perspective: Retrospective
Primary outcome: dead or alive
Detailed description:
The following variables will be followed: time and location of positive cultures,
underlying diseases and severity of illness, recent immunomodulative therapies, physical
exam findings, laboratory and radiographical data, antimicrobial usage, microbiological data
and resistance patterns, choice of antibiotics once organism is identified, suspected source
of infection, bacteriological outcomes, laboratory results, demographic information,
medications, clinical outcome, gender, height, weight, ethnicity, and past medical history.
Eligibility
Minimum age: 18 Years.
Maximum age: N/A.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Patients with Gram negative infections treated with piperacillin/tazobactam and/or
piperacillin
Locations and Contacts
University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, United States
Additional Information
Starting date: September 2005
Last updated: December 5, 2014
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