Effect of Combined Pharmacotherapy/Behavioral Treatment on Smoking Cessation For Methadone Maintenance Therapy Patients - 2
Information source: National Institute on Drug Abuse (NIDA)
Information obtained from ClinicalTrials.gov on August 07, 2007
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Tobacco Use Disorder
Intervention: Bupropion (Behavioral)
Phase: Phase 2
Status: No longer recruiting
Sponsored by: National Institute on Drug Abuse (NIDA) Official(s) and/or principal investigator(s):
Kimber Richter, Ph.D., Principal Investigator, Affiliation: University of Kansas
Summary
The purpose of this pilot study is to examine the effects of combined pharmacotherapy (Zyban/NRT)/behavioral treatment on smoking cessation among methadone maintenance therapy patients.
Clinical Details
Official title:
Pilot Study Examining the Effects of Combined Pharmacotherapy (Zyban/NRT)/Behavioral Treatment on Smoking Cessation Among MMT Patients.
Study design: Interventional, Treatment, Active Control
Primary outcome: Behavioral
Detailed description:
This is a one-arm, open label pilot study of MMT patients to determine whether bupropion, nicotine replacement therapy, and behavioral counseling is a feasible and potentially effective intervention for smoking cessation. The smoking behaviors of participants will be be followed for 6 months post quit-date to determine effect-size estimates for a future, large scale trial.
Eligibility
Minimum age: 18 Years.
Maximum age: 70 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Patients in long-term methadone maintenance treatment
- Patient smokes at least 10 cigarettes per day, are stable on their use of methadone (phase 2 or higher treatment), smoked for at least 1 year, be willing to participate for 6 months, and not have used bupropion or nicotine replacement therapy for 6 months
Exclusion Criteria:
- Patients who use prescription drug regimens that might affect methadone or bupropion metabolism
- Patients with cardiovascular disease, asthma, COPD
- Patients who are pregnant or breastfeeding
- Patients with regular use of alcohol, other illicit drugs, or other types of tobacco (chewing or pipe for example)
Locations and Contacts
University of Kansas Medical Center, Kansas City, Kansas 66160 7420, United States
Additional Information
Starting date:
September 2002
Last updated: November 3, 2005
|
