The Effect of MK0633 in Patients With Chronic Asthma

Condition(s) targeted: Asthma

Intervention: MK0633 (Drug); Comparator: Diltiazem (Drug); Comparator: Placebo (unspecified) (Drug)

Phase: Phase 2

Status: Recruiting

Sponsored by: Merck

Official(s) and/or principal investigator(s):
Medical Monitor, Study Director, Affiliation: Merck

Overall contact:
Toll Free Number, Phone: 1-888-577-8839

A clinical study to evaluate the efficacy and safety of MK0633 in adult patients with chronic asthma.

Official title: A Double-Blind, Randomized, Placebo-Controlled, Multicenter, Parallel-Group, Dose-Ranging Study of MK0633 in Adult Patients With Chronic Asthma

Study design: Treatment, Randomized, Double Blind (Subject, Investigator), Placebo Control, Parallel Assignment, Safety/Efficacy Study

Primary outcome: Pulmonary function test data measured over 6 weeks

Secondary outcome: Overall daytime and nighttime symptoms score, beta-agonist use, asthma exacerbations, asthma-specific quality of life questionnaire score, measured over 6 weeks

Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Documented clinical history of symptoms of chronic asthma, including dyspnea,

wheezing, chest tightness, cough, and/or sputum production

- Males and females 18-65 years of age

Exclusion Criteria:

- History of kidney or chronic liver disease

- Recent history of heart problems within the past 3 months

- Evidence of another clinically significant, active lung disorder such as

bronchiectasis or COPD

Toll Free Number, Phone: 1-888-577-8839

Merck Sharp & Dohme (Australia) Pty Ltd., South Granville NSW 2142, Australia; Recruiting
David Woolner, Phone: 64-9-523-6075

Merck Sharp & Dohme (I.A.) Corp., Santiago 6761641, Chile; Recruiting
Jorge Vinces, Phone: 51-1-411-5933

MSD Guatemala, Guatemala 1010, Guatemala; Recruiting
Patricia Salazar, Phone: 506-2210-0116

MSD Pharmaceuticals Private Ltd., New Delhi 110011, India; Recruiting
Swashraya Shah, Phone: 91-124-464-7338

Merck Sharp & Dohme Co. Ltd., Petah Tikva 49192, Israel; Recruiting
Raanan Cohen, Phone: 972-3-9274005

Merck Sharp & Dohme (I.A.) Corp, Selangor 46300, Malaysia; Recruiting
Nazrin Azli, Phone: 603-77181748

Merck Sharp & Dohme (New Zealand) Ltd.,, Auckland, New Zealand; Recruiting
David Woolner, Phone: 64-9523-6075

Call for Information, San Jose, California 95117, United States; Recruiting

Call for Information, San Diego, California 92123-0000, United States; Recruiting

Call for Information, San Diego, California 92103-8415, United States; Recruiting

Call for Information, Rolling Hills Estates, California 90274, United States; Recruiting

Call for Information, Riverside, California 92506, United States; Recruiting

Call for Information, Rancho Mirage, California 92270-0000, United States; Recruiting

Call for Information, Pasadena, California 91106, United States; Recruiting

Call for Information, Los Angeles, California 90048, United States; Recruiting

Call for Information, Long Beach, California 90808-0000, United States; Recruiting

Call for Information, Huntington Beach, California 92647, United States; Recruiting

Call for Information, Fresno, California 93720, United States; Recruiting

Merck Ltd., Japan, Tokyo, Chiyodaku 102-8667, Japan; Recruiting
Tadaaki Taniguchi, Phone: 81-3-6272-1547

Call for Information, Wheat Ridge, Colorado 80033-0000, United States; Recruiting

Call for Information, Norwalk, Connecticut 06850, United States; Recruiting

Frosst Laboratories Inc., Bogota, Cundinamarca, Colombia; Recruiting
Felipe Arbelaez, Phone: 57-1-592-4400

Merck Sharp & Dohme De Mexico, S.A. De C.V., Mexico, D.F. 1090, Mexico; Recruiting
Juan Diaz, Phone: 52-55-5481-9825

Call for Information, Winter Park, Florida 32789, United States; Recruiting

Call for Information, Tampa, Florida 33613-0000, United States; Recruiting

Call for Information, Tamarac, Florida 33321, United States; Recruiting

Call for Information, Orlando, Florida 32806, United States; Recruiting

Call for Information, Miami, Florida 33173, United States; Recruiting

Call for Information, Miami, Florida 33135, United States; Recruiting

Call for Information, Overland Park, Kansas 66210, United States; Recruiting

Call for Information, Louisville, Kentucky 40215, United States; Recruiting

Call for Information, Lexington, Kentucky 40536-0284, United States; Recruiting

Call for Information, Florence, Kentucky 41042, United States; Recruiting

Merck Sharp & Dohme, Peru S.R.L., Surquillo, Lima LIMA 34, Peru; Recruiting
Jorge Vinces, Phone: 511-411-5933

Call for Information, Metairie, Louisiana 70006, United States; Recruiting

Call for Information, North Dartmouth, Massachusetts 02747, United States; Recruiting

Call for Information, Saint Louis, Missouri 63110-1093, United States; Recruiting

Call for Information, Las Vegas, Nevada 89106, United States; Recruiting

Call for Information, Albuquerque, New Mexico 87108-5129, United States; Recruiting

Call for Information, Rochester, New York 14618, United States; Recruiting

Call for Information, Toledo, Ohio 43617, United States; Recruiting

Call for Information, Cincinnati, Ohio 45242, United States; Recruiting

Call for Information, Oklahoma City, Oklahoma 73120, United States; Recruiting

Call for Information, Philadelphia, Pennsylvania 19141, United States; Recruiting

Call for Information, Erie, Pennsylvania 16508, United States; Recruiting

Merck Frosst Canada Ltd., Kirkland, Quebec H9H 3L1, Canada; Recruiting
Michel Cimon, Phone: 514-428-2605

Call for Information, Charleston, South Carolina 29407, United States; Recruiting

Call for Information, Nashville, Tennessee 37208, United States; Recruiting

Call for Information, Waco, Texas 76712, United States; Recruiting

Call for Information, Leander, Texas 78641, United States; Recruiting

Call for Information, Killeen, Texas 76543, United States; Recruiting

Call for Information, Galveston, Texas 77555-0561, United States; Recruiting

Call for Information, Austin, Texas 78750, United States; Recruiting

Call for Information, Midvale, Utah 84047, United States; Recruiting

Call for Information, Layton, Utah 84041, United States; Recruiting

Call for Information, Tacoma, Washington 98405, United States; Recruiting

Starting date: January 2008
Last updated: October 29, 2008