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Trial of Oxytocin Alone Versus Oxytocin and Propranolol for the Treatment of Abnormal Labor

Information source: University of California, Irvine
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Dysfunctional Labor

Intervention: Propranolol (Drug); IV Placebo (Other)

Phase: Phase 2

Status: Terminated

Sponsored by: University of California, Irvine

Official(s) and/or principal investigator(s):
Leah R Battista, MD, Principal Investigator, Affiliation: University of California, Irvine


The purpose of this study is to determine whether propranolol is better than oxytocin for the treatment of labor abnormalities. The endpoint is the rate of vaginal delivery experienced by women receiving prolonged oxytocin versus propranolol.

Clinical Details

Official title: Placebo-Controlled Randomized Trial of Oxytocin Alone Versus Oxytocin and Propranolol for the Treatment of Dysfunctional Labor

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Primary outcome:

Vaginal delivery rates

Cesarean section rates

Secondary outcome:

Neonatal outcomes

Maternal safety

Detailed description: This trial was designed to test if propranolo can reduce the c section rate for dysfuctional labor. Due to stringent inclution and exclusion criteria and low enrollment the study was closed.


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Female.


Inclusion Criteria:

- Must be term pregnancy (> 37 weeks)

- Vertex presentation

- Active labor (4-5 centimeters dilated)

Exclusion Criteria:

- Heart disease

- Diabetes

- Currently taking propranolol

- Contraindications to labor or vaginal delivery

- Multiple gestations

- Preterm

- Chorioamnionitis

Locations and Contacts

Long Beach Memorial Medical Center, Long Beach, California 90806, United States
Additional Information

Starting date: January 2004
Last updated: December 5, 2014

Page last updated: August 23, 2015

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