The Effects of Craving and Abstinence From Cigarettes on Brain Metabolism in Smokers
Information source: Tel-Aviv Sourasky Medical Center
Information obtained from ClinicalTrials.gov on June 20, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Nicotine Dependence
Intervention: Bupropion (Zyban) (Drug)
Phase: N/A
Status: Completed
Sponsored by: Tel-Aviv Sourasky Medical Center Official(s) and/or principal investigator(s):
Einat Even-Sapir, M.D, Ph.D, Principal Investigator, Affiliation: Tel-Aviv Sourasky Medical Center
Aviv M Weinstein, Ph.D, Principal Investigator, Affiliation: Tel-Aviv Sourasky Medical Center
Hedva Lerman, M.D, Study Director, Affiliation: Tel-Aviv Sourasky Medical Center
Summary
Craving and withdrawal from smoking cigarettes are major factors for relapse. We investigated
craving for cigarettes in smokers undergoing pharmacological treatment with Bupropion
(Zyban). We compare cue-induced reactivity to smoking videos in smokers who were successfully
treated with Bupropion to smokers who are still smoking. We measured the brain's metabolic
activity in response to smoking and neutral cues in Positron Emission Tomography using FDG.
Clinical Details
Official title: The Effects of Craving and Abstinence From Cigarettes on Brain Metabolism in Smokers.
Study design: Treatment, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Pharmacodynamics Study
Primary outcome: Brain metabolic activity (FDG) in response to craving and neutral cues.
Secondary outcome: Subjective ratings of craving
Detailed description:
Craving and withdrawal from smoking cigarettes are major factors for relapse. We investigated
craving for cigarettes in smokers undergoing pharmacological treatment with Bupropion
(Zyban)for 2 months. We compare cue-induced reactivity to smoking videos in smokers who were
successfully treated with Bupropion to smokers who are still smoking. We measured the brain's
metabolic activity after exposure to videotapes showing smoking and neutral scenes in
Positron Emission Tomography using FDG. There were 2 scanning sessions, one with a smoking
videotape and one with a neutral video separated by a week. So far we have compared the
brain's metabolic activity in 6 abstinent smokers and 6 still smokers.
Eligibility
Minimum age: 20 Years.
Maximum age: 65 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Cigarette smokers (over 1 pack a day)
- Age 20-65, male-females
Exclusion Criteria:
- Dependence on other substances
- Psychiatric diagnosis
- Neurological disorder
- Obesity
- Young persons
- Pregnant women
Locations and Contacts
Department of Nuclear Medicine, Tel Aviv 64239, Israel
Additional Information
Starting date: July 2004
Ending date: October 2007
Last updated: May 6, 2008
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