Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis
Information source: Facultad Nacional de Salud Publica
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Aggressive Periodontitis
Intervention: scaling and systemic moxifloxacin (Other); scaling and root planing (Other)
Phase: Phase 4
Status: Completed
Sponsored by: Facultad Nacional de Salud Publica Official(s) and/or principal investigator(s):
Carlos M Ardila, Ph.D, Principal Investigator, Affiliation: Universidad de Antioquia
Summary
The adjunctive use of systemically administered antibiotics has been shown to provide a
better clinical outcome, particularly in terms of probing depth (PD) reduction and
attachment-level gain than SRP in subjects with Aggressive Periodontitis.
The overall objective of this study is to evaluate the clinical and microbiological efficacy
of moxifloxacin as an adjunct to scaling and root planing versus scaling and root planing
over placebo in the treatment of aggressive periodontitis.
Clinical Details
Official title: Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis: Double-blind Controlled Clinical Trial
Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
Primary outcome: probing depth
Secondary outcome: clinical attachment level and probing depth
Eligibility
Minimum age: 15 Years.
Maximum age: 30 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- under 30 years old and systemically healthy, with at least 20 teeth present. Be
willing to participate in the study which is corroborated by signing the informed
consent form.
Commit to attend post-therapeutic controls and stop drinking alcohol during the time of
ingestion of antibiotics.
Exclusion Criteria:
- Subjects in whom are contraindicated or with hypersensitivity to quinolones -
Subjects who have undergone periodontal, surgical or mechanical antibiotic therapy
six months before the start of the study according to interrogation.
Women in pregnancy or lactation, corroborated with previous medical history and medical
consultation.
Locations and Contacts
Faculty of Dentistry, Departamento de Antioquia, Medellin, Colombia
Additional Information
Universidad de Antioquia
Starting date: August 2011
Last updated: May 29, 2014
|
