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Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis

Information source: Facultad Nacional de Salud Publica
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Aggressive Periodontitis

Intervention: scaling and systemic moxifloxacin (Other); scaling and root planing (Other)

Phase: Phase 4

Status: Completed

Sponsored by: Facultad Nacional de Salud Publica

Official(s) and/or principal investigator(s):
Carlos M Ardila, Ph.D, Principal Investigator, Affiliation: Universidad de Antioquia

Summary

The adjunctive use of systemically administered antibiotics has been shown to provide a better clinical outcome, particularly in terms of probing depth (PD) reduction and attachment-level gain than SRP in subjects with Aggressive Periodontitis. The overall objective of this study is to evaluate the clinical and microbiological efficacy of moxifloxacin as an adjunct to scaling and root planing versus scaling and root planing over placebo in the treatment of aggressive periodontitis.

Clinical Details

Official title: Adjunctive Systemic Administration of Moxifloxacin in the Treatment of Aggressive Periodontitis: Double-blind Controlled Clinical Trial

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Primary outcome: probing depth

Secondary outcome: clinical attachment level and probing depth

Eligibility

Minimum age: 15 Years. Maximum age: 30 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- under 30 years old and systemically healthy, with at least 20 teeth present. Be

willing to participate in the study which is corroborated by signing the informed consent form. Commit to attend post-therapeutic controls and stop drinking alcohol during the time of ingestion of antibiotics. Exclusion Criteria:

- Subjects in whom are contraindicated or with hypersensitivity to quinolones -

Subjects who have undergone periodontal, surgical or mechanical antibiotic therapy six months before the start of the study according to interrogation. Women in pregnancy or lactation, corroborated with previous medical history and medical consultation.

Locations and Contacts

Faculty of Dentistry, Departamento de Antioquia, Medellin, Colombia
Additional Information

Universidad de Antioquia

Starting date: August 2011
Last updated: May 29, 2014

Page last updated: August 23, 2015

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