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Dexamethasone for the Prevention of Postoperative Cognitive Dysfunction

Information source: University of Sao Paulo
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Postoperative Cognitive Dysfunction

Intervention: Dexamethasone (Drug); control group (Other)

Phase: Phase 4

Status: Recruiting

Sponsored by: University of Sao Paulo

Overall contact:
Maria J.C. Carmona, M.D., Phone: 55-11-3069-6335, Email: maria.carmona@incor.usp.br

Summary

This study aims to evaluate the possible effect of dexamethasone on prevention of cognitive dysfunction in the postoperative period of elderly patients undergoing to surgery under general anesthesia.

Clinical Details

Official title: Dexamethasone for the Prevention of Postoperative Cognitive Dysfunction in Elderly Patients Undergoing to General Anesthesia

Study design: Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Primary outcome: Score in neuropsycological tests.

Detailed description: Postoperative cognitive dysfunction is related with the use of opioids in the postoperative period, lack of physical activity, fatigue, postoperative pain and quality of life. The use of corticosteroids preoperatively reduces postoperative pain, fatigue, nausea and vomiting in the postoperative period and is frequently used as an adjuvant in anesthesia. This study aims to evaluate the possible effect of dexamethasone on prevention of cognitive dysfunction in the postoperative period of elderly patients undergoing to surgery under general anesthesia.

Eligibility

Minimum age: 60 Years. Maximum age: 90 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- patients over 60 years,

- underwent surgery for inguinal hernia repair, Nissen procedure, cholecystectomy or

other surgeries midsize under general anesthesia and hospital stay expected within 72 hours. Exclusion Criteria:

- age less than 60 years,

- history of brain disease or dementia, other psychiatric disorders that affect

cognition,

- lack of proficiency in Portuguese,

- use of corticosteroids or opioid preoperatively.

Locations and Contacts

Maria J.C. Carmona, M.D., Phone: 55-11-3069-6335, Email: maria.carmona@incor.usp.br

General Hospital of the University of São Paulo Medical School, São Paulo 05403-000, Brazil; Recruiting
Maria JC Carmona, Carmona, Phone: 55-11-3069-6335, Email: maria.carmona@incor.usp.br
Lívia SS Valentin, Psy, Email: lssv@usp.com.br
Lívia SS Valentin, Psy, Sub-Investigator
Maria JC Carmona, MD, Principal Investigator
Additional Information

Starting date: January 2011
Last updated: January 3, 2013

Page last updated: August 23, 2015

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