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Left Ventricular Hypertrophy and Spironolactone in End Stage Renal Disease

Information source: West Penn Allegheny Health System
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Kidney Failure, Chronic

Intervention: Spironolactone (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: West Penn Allegheny Health System

Official(s) and/or principal investigator(s):
Richard Marcus, Principal Investigator, Affiliation: West Penn Allegheny Health System


The hypothesis of this trial is to assess the effect of spironolactone on heart size and mass

Clinical Details

Study design: Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Primary outcome: Left ventricular mass

Detailed description: Dialysis patients have significant morbidity and mortality associated with left ventricular hypertrophy and cardiac failure. Aldosterone may have an important role in the development of myocardial hypertrophy and remodeling. Animal studies have demonstrated beneficial effects of aldosterone antagonists on myocardial hypertrophy, and human studies have shown significant survival benefit in a non-dialysis population with congestive heart failure. This study evaluates the effect of spironolactone (an aldosterone receptor antagonist) on cardiac hypertrophy in the end-stage renal disease population.


Minimum age: 18 Years. Maximum age: N/A. Gender(s): Both.


Inclusion Criteria:

- hemodialysis patients

Exclusion Criteria:

- non compliance

- hyperkalemia

- pregnancy

- expected survival less than 9 months

Locations and Contacts

Allegheny General Hospital, Pittsburgh, Pennsylvania 15212, United States
Additional Information

Last updated: October 23, 2007

Page last updated: August 23, 2015

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