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A Comparison of Mometasone to Advair in Patients With Milder Persistent Asthma

Information source: Johns Hopkins University
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Asthma

Intervention: Mometasone or Advair (Drug)

Phase: Phase 4

Status: Recruiting

Sponsored by: Johns Hopkins University

Official(s) and/or principal investigator(s):
Peter S Creticos, MD, Principal Investigator, Affiliation: Johns Hopkins University

Overall contact:
Arouna P Khattignavong, MD, Phone: 410-550-2184, Email: akhatti1@jhmi.edu

Summary

The research hypothesis for the proposed study asks the question, can Asmanex® demonstrate comparable anti-inflammatory therapeutic efficacy to the combination product, Advair® in control of mild persistent asthma? The purpose is to demonstrate that the anti-inflammatory protection afforded by monotherapy with an inhaled steroid (Asmanex®) is comparable to combination therapy with Advair® 100/50, when measured by this standard methodology (methacholine bronchoprovocation) in subjects with mild persistent asthma.

Clinical Details

Official title: A Single-Blind, Randomized, Positive-Controlled Study to Compare Monotherapy With an Inhaled Corticosteroid (Mometasone) to Combination Therapy With an Inhaled Corticosteroid + a Long-Acting Bronchodilator (Advair) in Patients With Milder Persistent Asthma

Study design: Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind, Primary Purpose: Treatment

Eligibility

Minimum age: 18 Years. Maximum age: 65 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- subjects 18 to 65 years of age

- a >2 year history of asthma

- FEV1 > 80% for subjects currently using Advair®.

Exclusion Criteria:

- severe asthma

- current smokers

- pregnant or breast-feeding women

- other chronic significant illnesses

Locations and Contacts

Arouna P Khattignavong, MD, Phone: 410-550-2184, Email: akhatti1@jhmi.edu

Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224, United States; Recruiting
Peter S Creticos, MD, Principal Investigator
Additional Information

Starting date: April 2007
Last updated: April 16, 2007

Page last updated: August 23, 2015

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