Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane
Information source: Melbourne Health
Information obtained from ClinicalTrials.gov on November 03, 2008
Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Anaesthesia; Dreaming
Intervention: Propofol (Drug); desflurane (Drug)
Phase: Phase 4
Status: Recruiting
Sponsored by: Melbourne Health Official(s) and/or principal investigator(s):
Kate Leslie, MD, Principal Investigator, Affiliation: Melbourne Health
Overall contact:
Kate Leslie, MD, Phone: 61-3-93427000, Email: kate.leslie@mh.org.au
Summary
We hypothesise that patients who receive propofol for maintenance of anaesthesia will report
dreaming more often when they emerge from anaesthesia than patients who receive desflurane
for maintenance of anaesthesia.
Clinical Details
Official title: Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane
Study design: Diagnostic, Randomized, Double-Blind, Active Control, Parallel Assignment, Pharmacodynamics Study
Primary outcome: Incidence of dreaming reported by patients interviewed immediately on emergence from anaesthesia using a standardised questionnaire
Detailed description:
Patients commonly report that they have been dreaming when they emerge from anaesthesia. Data
from observational studies and small randomised trials suggests that reports of dreaming are
more commonly made after anaesthesia maintained with propofol than anaesthesia maintained
with inhaled anaesthetic agents. We propose to randomise 300 healthy patients to receive a
standardised general anaesthetic for surgery that includes either propofol or desflurane for
maintenance. We will measure the raw and processed electroencephalogram during and after
anaesthesia and interview patients about dreaming as soon as they emerge from anaesthesia.
Eligibility
Minimum age: 18 Years.
Maximum age: 50 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Male and female patients
- Age between 18 and 50 years
- Presenting for elective surgery under general anaesthesia
Exclusion Criteria:
- Inadequate English language comprehension
- Major drug abuse problem
Locations and Contacts
Kate Leslie, MD, Phone: 61-3-93427000, Email: kate.leslie@mh.org.au
Waikato Hospital, Hamilton, New Zealand; Recruiting
Jamie Sleigh, MD, Phone: 64-7-8398899, Email: sleighj@waikatodhb.govt.nz
Michael Paech, MD, Principal Investigator
Royal Melbourne Hospital, Parkville, Victoria 3050, Australia; Recruiting
Kate Leslie, MD, Phone: 61-3-93427000, Email: kate.leslie@mh.org.au
Kate Leslie, MD, Principal Investigator
Royal Perth Hospital, Perth, Western Australia 6000, Australia; Recruiting
Michael Paech, MD, Phone: 61-8-9340 2222, Email: michael. paech@health.wa.gov.au
Michael Paech, MD, Principal Investigator
King Edward Memorial Hospital for Women, Subiaco, Western Australia 6008, Australia; Recruiting
Michael Paech, MD, Phone: 61-8-9340 2222, Email: michael.paech@health.wa.gov.au
Michael Paech, MD, Principal Investigator
Additional Information
Starting date: August 2006
Ending date: August 2007
Last updated: March 8, 2007
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