Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane
Information source: Melbourne Health
ClinicalTrials.gov processed this data on August 23, 2015 Link to the current ClinicalTrials.gov record.
Condition(s) targeted: Anaesthesia
Intervention: Propofol (Drug); desflurane (Drug)
Phase: Phase 4
Status: Completed
Sponsored by: Melbourne Health Official(s) and/or principal investigator(s): Kate Leslie, MD, Principal Investigator, Affiliation: Melbourne Health
Summary
We hypothesise that patients who receive propofol for maintenance of anaesthesia will report
dreaming more often when they emerge from anaesthesia than patients who receive desflurane
for maintenance of anaesthesia.
Clinical Details
Official title: Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane
Study design: Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Diagnostic
Primary outcome: Incidence of dreaming reported by patients interviewed immediately on emergence from anaesthesia using a standardised questionnaire
Detailed description:
Patients commonly report that they have been dreaming when they emerge from anaesthesia.
Data from observational studies and small randomised trials suggests that reports of
dreaming are more commonly made after anaesthesia maintained with propofol than anaesthesia
maintained with inhaled anaesthetic agents. We propose to randomise 300 healthy patients to
receive a standardised general anaesthetic for surgery that includes either propofol or
desflurane for maintenance. We will measure the raw and processed electroencephalogram
during and after anaesthesia and interview patients about dreaming as soon as they emerge
from anaesthesia.
Eligibility
Minimum age: 18 Years.
Maximum age: 50 Years.
Gender(s): Both.
Criteria:
Inclusion Criteria:
- Male and female patients
- Age between 18 and 50 years
- Presenting for elective surgery under general anaesthesia
Exclusion Criteria:
- Inadequate English language comprehension
- Major drug abuse problem
Locations and Contacts
Waikato Hospital, Hamilton, New Zealand
Royal Melbourne Hospital, Parkville, Victoria 3050, Australia
Royal Perth Hospital, Perth, Western Australia 6000, Australia
King Edward Memorial Hospital for Women, Subiaco, Western Australia 6008, Australia
Additional Information
Starting date: August 2006
Last updated: May 28, 2013
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