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Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane

Information source: Melbourne Health
ClinicalTrials.gov processed this data on August 23, 2015
Link to the current ClinicalTrials.gov record.

Condition(s) targeted: Anaesthesia

Intervention: Propofol (Drug); desflurane (Drug)

Phase: Phase 4

Status: Completed

Sponsored by: Melbourne Health

Official(s) and/or principal investigator(s):
Kate Leslie, MD, Principal Investigator, Affiliation: Melbourne Health

Summary

We hypothesise that patients who receive propofol for maintenance of anaesthesia will report dreaming more often when they emerge from anaesthesia than patients who receive desflurane for maintenance of anaesthesia.

Clinical Details

Official title: Dreaming and EEG Changes During Anaesthesia Maintained With Propofol or Desflurane

Study design: Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Outcomes Assessor), Primary Purpose: Diagnostic

Primary outcome: Incidence of dreaming reported by patients interviewed immediately on emergence from anaesthesia using a standardised questionnaire

Detailed description: Patients commonly report that they have been dreaming when they emerge from anaesthesia. Data from observational studies and small randomised trials suggests that reports of dreaming are more commonly made after anaesthesia maintained with propofol than anaesthesia maintained with inhaled anaesthetic agents. We propose to randomise 300 healthy patients to receive a standardised general anaesthetic for surgery that includes either propofol or desflurane for maintenance. We will measure the raw and processed electroencephalogram during and after anaesthesia and interview patients about dreaming as soon as they emerge from anaesthesia.

Eligibility

Minimum age: 18 Years. Maximum age: 50 Years. Gender(s): Both.

Criteria:

Inclusion Criteria:

- Male and female patients

- Age between 18 and 50 years

- Presenting for elective surgery under general anaesthesia

Exclusion Criteria:

- Inadequate English language comprehension

- Major drug abuse problem

Locations and Contacts

Waikato Hospital, Hamilton, New Zealand

Royal Melbourne Hospital, Parkville, Victoria 3050, Australia

Royal Perth Hospital, Perth, Western Australia 6000, Australia

King Edward Memorial Hospital for Women, Subiaco, Western Australia 6008, Australia

Additional Information

Starting date: August 2006
Last updated: May 28, 2013

Page last updated: August 23, 2015

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